IMPLANTABLE MEDICAL DEVICE AND A METHOD COMPRISING MEANS FOR DETECTING AND CLASSIFYING VENTRICULAR TACHYARRHYTMIAS (As Amended)

• US 20100179411A1
• Filed: 06/13/2007
• Published: 07/15/2010
• Est. Priority Date: 06/13/2007
• Status: Active Grant

• Current Assignee: St. Jude Medical AB (Abbott Laboratories)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories)
• Inventors: Hedberg, Sven-Erik, Öhlander, Malin, Blomqvist, Andreas, Holmström, Nils
• Granted Patent: US 8,321,016 B2
• Time in Patent Office: Days
• US Class Current: 600/374
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

In a method and implantable medical device for ventricular tachyarrhythmia detection and classification, upon detection of a ventricular tachyarrhythmia based on an electrocardiogram signal, cardiogenic impedance data representative of ventricular volume dynamics are collected and used for classifying the detected tachyarrhythmia as stable or unstable. In the latter case but typically not in the former case, defibrillation shocks or other forms of therapy are applied to combat the unstable ventricular tachyarrhythmia.

Claims

1. An implantable medical device comprising:

a tachyarrhythmia detector that detects a ventricular tachyarrhythmia in a heart of a subject based on an electrocardiogram signal measured for said heart;

an impedance determining unit that determines a cardiogenic impedance signal representative of volumetric dynamics of at least one ventricle of said heart; and

a tachyarrhythmia classifier that classifies said ventricular tachyarrhythmia as a stable ventricular tachyarrhythmia or an unstable ventricular tachyarrhythmia based on said cardiogenic impedance signal.

2. The device according to claim 1, wherein said impedance determining unit (120) comprises:

a signal applier that applies, in response to said tachyarrhythmia detector detecting said ventricular tachyarrhythmia, a current signal or a voltage signal to at least a portion of said heart;

a signal measurer that measures a resulting voltage signal or a resulting current signal over at least a portion of said heart; and

a signal processor that determines said cardiogenic impedance signal based on said applied current or voltage signal and said measured resulting voltage or current signal.

3. The device according to claim 1, further comprising a lead input connected to said impedance determining unit and connectable to at least one intracardiac lead having at least one electrode for performing a quadropolar or tripolar impedance vector measurement.

4. The device according to claim 3, wherein said lead input is connectable to a right ventricle intracardiac lead having at least one electrode and a left ventricle intracardiac lead having at least one electrode, and wherein said impedance determining unit that determines said cardiogenic impedance signal using a quadropolar or tripolar impedance vector between said at least one electrode of said right ventricle intracardiac lead and said at least one electrode of said left ventricle intracardiac lead (320).

5. The device according to claim 3, wherein said lead input is connectable to a right atrium intracardiac lead having at least one electrode and a right ventricle intracardiac lead having at least one electrode, and wherein said impedance determining unit determines said cardiogenic impedance signal using a quadropolar or tripolar impedance vector between said at least one electrode of said right atrium intracardiac lead and said at least one electrode of said right ventricle intracardiac lead.

6. The device according to claim 1, wherein said impedance determining unit i) measurers cardiogenic impedance during multiple time periods of different heart beats and ii) determines said cardiogenic impedance signal as an average of said cardiogenic impedance measured during different heart beats.

7. The device according to claim 1, wherein said tachyarrhythmia detector detects said ventricular tachyarrhythmia by detecting a presence of a premature ventricular contraction or irregular atrio-ventricular synchrony as determined by processing said measured electrocardiogram signal.

8. The device according to claim 1, wherein said tachyarrhythmia detector detects said ventricular tachyarrhythmia based on a heart rate of said heart determined from said electrocardiogram signal.

9. The device according to claim 1, wherein said tachyarrhythmia classifier comprises a comparator that compares said cardiogenic impedance signal with a defined signal template, said tachyarrhythmia classifier (130) is arranged for classifying said ventricular tachyarrhythmia as a stable ventricular tachyarrhythmia or an unstable ventricular tachyarrhythmia based on said comparison performed by said comparator (134).

10. The device according to claim 9, further comprising a state defining unit that defines a current subject state of said subject, and wherein said tachyarrhythmia classifier comprises a template selector that selects a defined signal template from a set of multiple defined signal templates based on said current subject state defined by said state defining unit, each defined signal template being associated with a given subject state, and wherein said comparator comparers said cardiogenic impedance signal with said defined signal template selected by said template selector.

11. The device according to claim 10, wherein said state defining unit is a heart rate unit that measures a heart rate of said subject, and wherein said template selector selects a defined signal template from said set of multiple defined signal templates based on said heart rate measured by said heart rate unit, each defined signal template being associated with a given heart rate interval.

12. The device according to claim 10, wherein said state defining unit is a posture unit that determines a body posture of said subject, and wherein said template selector selects a defined signal template from said set of multiple defined signal templates based on said body posture determined by said posture unit, each defined signal template being associated with a given body posture.

13. The device according to claim 9, wherein said comparator performs a morphological comparison of said cardiogenic impedance signal and said defined signal template.

14. The device according to claim 9, wherein said impedance determining unit measures a cardiogenic impedance representative of volumetric dynamics of at least one ventricle of said heart during a period of no ventricular tachyarrhythmia, and wherein said implantable medical device further comprises a template unit that determines said defined signal template based on said cardiogenic impedance measured by said impedance determining unit.

15. The device according to claim 14, wherein said template unit intermittently updates said defined signal template based on cardiogenic impedances representative of volumetric dynamics of at least one ventricle of said heart measured by said impedance measuring unit during different periods of no ventricular tachyarrhythmia.

16. The device according to claim 9, wherein said impedance determining unit measures a cardiogenic impedance representative of volumetric dynamics of at least one ventricle of said heart during a period of stable ventricular tachyarrhythmia, and wherein said implantable medical device further comprises a template unit that determines said defined signal template based on said cardiogenic impedance measured by said impedance determining unit.

17. A heart conditioning method comprising the steps of:

detecting a ventricular tachyarrhythmia in a heart of a subject based on an electrocardiogram signal measured for said heart;

determining a cardiogenic impedance signal representative of volumetric dynamics of at least one ventricle of said heart; and

classifying said ventricular tachyarrhythmia as a stable ventricular tachyarrhythmia or an unstable ventricular tachyarrhythmia based on said cardiogenic impedance signal.

18. The method according to claim 17, wherein said determining step comprises determining, based on said detection of said ventricular tachyarrhythmia, said cardiogenic impedance signal.

19. The method according to claim 17, wherein said determining step comprises determining said cardiogenic impedance signal using a quadropolar or tripolar impedance vector.

20. The method according to claim 19, wherein said determining step comprises determining said cardiogenic impedance signal using a quadropolar or tripolar impedance vector between a left ventricle and a right ventricle of said heart.

21. The method according to claim 19, wherein said determining step comprises determining said cardiogenic impedance signal using a quadropolar or tripolar impedance vector between a right atrium and a right ventricle of said heart.

22. The method according to claim 17, wherein said determining step comprises the steps of:

measuring cardiogenic impedance during multiple time periods of different heart beats; and

determining said cardiogenic impedance signal as an average of said cardiogenic impedance measured during different heart beats.

23. The method according to claim 17, wherein said detecting step comprises the steps of:

determining an electrocardiogram signal in said heart; and

detecting said ventricular tachyarrhythmia by detecting a presence of a premature ventricular contraction or an irregular atrio-ventricular synchrony in said electrocardiogram signal.

24. The method according to claim 17, wherein said detecting step comprises the steps of:

determining a heart rate of said heart based on said electrocardiogram signal; and

detecting said detecting said ventricular tachyarrhythmia based on said determined heart rate.

25. The method according to claim 17, wherein said classifying step comprises the steps of:

comparing said cardiogenic impedance signal with a defined signal template; and

classifying said ventricular tachyarrhythmia as a stable ventricular tachyarrhythmia or an unstable ventricular tachyarrhythmia based on said comparison.

26. The method according to claim 25, wherein said comparing step comprises the steps of:

defining a current subject state of said subject;

selecting a defined signal template from a set of multiple defined signal templates based on said defined subject state, where each defined signal template is associated with a given subject state; and

comparing said cardiogenic impedance signal with said selected, defined signal template.

27. The method according to claim 26, wherein said defining step comprises measuring a heart rate of said subject, and said selecting step comprises selecting a defined signal template from said set of multiple defined signal templates based on said measured heart rate, where each defined signal template is associated with a given heart rate interval.

28. The method according to claim 26, wherein said defining step comprises determining a body posture of said subject, and said selecting step comprises selecting a defined signal template from said set of multiple defined signal templates based on said determined body posture, where each defined signal template is associated with a given body posture.

29. The method according to claim 25, wherein said comparing step comprises performing a morphological comparison of said cardiogenic impedance signal and said defined signal template.

30. The method according to claim 25, further comprising the steps of:

measuring a cardiogenic impedance representative of volumetric dynamics of at least one ventricle of said heart during a period of no ventricular tachyarrhythmia; and

determining said defined signal template based on said measured cardiogenic impedance.

31. The method according to claim 30, further comprising intermittently updating said defined signal template based on measured cardiogenic impedances representative of volumetric dynamics of at least one ventricle of said heart during different periods of no ventricular tachyarrhythmia.

32. The method according to claim 25, further comprising the steps of:

measuring a cardiogenic impedance representative of volumetric dynamics of at least one ventricle of said heart during a period of stable ventricular tachyarrhythmia; and

determining said defined signal template based on said measured cardiogenic impedance.