METHOD FOR PREPARING AN IMPLANTABLE CONTROLLED GENE OR PROTEIN DELIVERY DEVICE
First Claim
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1. A method to prepare an implantable gene or protein delivery device including isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA in a mammal or isolated protein, comprising:
- introducing to a physiologically compatible polymer matrix, or combining physiologically compatible monomers suitable to form a polymeric matrix and, the isolated nucleic acid or isolated protein so as to yield an implantable gene or protein delivery device, wherein the isolated nucleic acid or protein is selected so as to prevent, inhibit or treat a cardiac condition in a mammal, and wherein the rate of release of the nucleic acid or protein from the device is capable of being controlled by an electric signal.
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Abstract
An implantable system which includes a gene/protein delivery device and a pulse generator, as well as method of preparing the gene/protein delivery device and using the system, are provided. In one embodiment, the implantable system detects a predetermined condition or event and, in response, delivers gene(s) and/or protein(s) in conjunction with delivering pacing and/or defibrillation pulses.
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20 Claims
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1. A method to prepare an implantable gene or protein delivery device including isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA in a mammal or isolated protein, comprising:
introducing to a physiologically compatible polymer matrix, or combining physiologically compatible monomers suitable to form a polymeric matrix and, the isolated nucleic acid or isolated protein so as to yield an implantable gene or protein delivery device, wherein the isolated nucleic acid or protein is selected so as to prevent, inhibit or treat a cardiac condition in a mammal, and wherein the rate of release of the nucleic acid or protein from the device is capable of being controlled by an electric signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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