DEVICE AND METHOD FOR TREATING ISCHEMIC HEART DISEASE

• US 20100179643A1
• Filed: 12/07/2009
• Published: 07/15/2010
• Est. Priority Date: 03/27/2000
• Status: Abandoned Application

• Current Assignee: Shockwave Medical, Incorporated (Johnson & Johnson)
• Original Assignee: Neovasc Medical Ltd. (Neovasc Incorporated)
• Inventors: Shalev, Ilan
• Application Number:
  US12/632,762
• Publication Number:
  US 20100179643A1
• Time in Patent Office: Days
• US Class Current: 623/1.310
• CPC Class Codes: A61F 2/01 Filters implantable into blood vessels
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2002/068 Modifying the blood flow model, e.g. by diffuser or deflector
• CPC Class Codes: A61F 2002/91525 within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/9155 Adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2250/0039 differing in diameter

Abstract

A narrowing intraluminal stent is disclosed and comprises a hollow body and a flow passage therethrough, the hollow body designed for intraluminal placement and having “at least one portion of an inner cross sectional dimension smaller than the cross sectional dimension of the lumen, so as to artificially narrow a passage through the body lumen. A method of artificially narrowing a passage through a body lumen using the stent is also disclosed.

Claims

1. A method of affecting blood flow in coronary vessels, comprising:

(a) transvascularly guiding a catheter to a coronary sinus; and

(b) narrowing a cross-sectional dimension of a flow lumen of said coronary sinus by implanting a flow reducer in said flow lumen using said catheter, said flow reducer having a cross-sectional dimension that is smaller than a cross-sectional dimension of said flow lumen;

wherein said cross-sectional dimension of said flow reducer is non-expandable.

2. A method according to claim 1, wherein said flow reducer is implanted using a balloon.

3. A method according to claim 1, wherein said flow reducer is a self-expanding reducer.

4. A method according to claim 1, wherein narrowing comprises narrowing in a manner that increases back pressure.

5. A method according to claim 1, wherein narrowing comprises narrowing in a manner that initiates angiogenesis.

6. A method according to claim 1, wherein narrowing comprises narrowing in a manner that accelerates angiogenesis.

7. A method according to claim 1, wherein narrowing comprises narrowing in a manner that prevents ischemic heart disease.

8. A method according to claim 1, wherein narrowing comprises permanently narrowing.

9. A method according to claim 1, comprising:

determining that a patient has ischemic heart disease; and

performing (a)-(b).

10. A method according to claim 1, comprising reducing said a diameter of said cross-section of said flow lumen by a factor of at least 2.6.

11. A method of improving perfusion of a tissue, comprising:

(a) identifying a tissue having a deficient degree of blood flow there through; and

(b) transvascularly narrowing a cross-sectional diameter of a vessel carrying blood from said tissue, said narrowing comprising deploying a flow reducer in the vessel, said flow reducer having a cross-sectional dimension that is smaller than a cross-sectional dimension of said flow lumen, said narrowing being effective to cause improvement in blood flow through the tissue.

12. A method according to claim 11, wherein said vessel comprises a coronary sinus.

13. A method according to claim 11, wherein said tissue comprises cardiac tissue.

14. A method according to claim 11, wherein said narrowing is sufficient to cause angiogenesis in said tissue.

15. A method of affecting blood flow in a coronary vessel, comprising:

narrowing a cross-sectional dimension of said coronary vessel, wherein said narrowing comprises deploying a flow reducer in said coronary vessel, said flow reducer being formed of a single element configured to include;

at least one portion having an inner cross-sectional dimension smaller than that of said coronary vessel, said inner cross-sectional dimension being non-expandable; and

at least one expandable portion, each of said at least one expandable portion being disposed at a specific position along the length of said flow reducer;

wherein said deploying comprises expanding said at least one expandable portion such that said flow reducer is fixed in said coronary vessel.

16. A method according to claim 15, wherein said at least one portion having an inner cross-sectional dimension smaller than that of said coronary vessel comprises:

a central portion having an inner cross-sectional dimension smaller than that of said coronary vessel; and

wherein said at least one expandable portion includes an expandable portion at each of first and second ends of said flow reducer.

17. A method of affecting blood flow in a coronary sinus, comprising:

(a) providing a flow reducer having a specific length;

(b) narrowing a cross-sectional dimension of a flow lumen of said coronary sinus, wherein said narrowing comprises deploying said flow reducer in the coronary sinus, said flow reducer having a non-expandable cross-sectional diameter that is smaller than a cross-sectional diameter of said flow lumen, whereby the length of said flow reducer is substantially maintained.