MEDICAL DEVICES HAVING MULTIPLE LAYERS
First Claim
Patent Images
1. A medical device comprising a multilayer region that comprises:
- (a) a charged nanoparticle layer comprising charged nanoparticles;
(b) a plurality of charged polyelectroyte layers comprising charged polyelectrolyte species, and(c) at least one charged therapeutic agent,wherein said medical device is configured for implantation or insertion into a subject.
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Accused Products
Abstract
Described herein are medical devices which are configured for implantation or insertion into a subject, preferably a mammalian subject. The medical devices contain one or more multilayer regions, which contain: (a) one or more (typically a plurality of) charged nanoparticle layers and (b) one or more (typically a plurality of) charged polyelectroyte layers. Such multilayers have a number of desirable attributes, including high strength, non-compliance, and flexibility. Also described herein are methods of making such devices.
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Citations
60 Claims
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1. A medical device comprising a multilayer region that comprises:
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(a) a charged nanoparticle layer comprising charged nanoparticles; (b) a plurality of charged polyelectroyte layers comprising charged polyelectrolyte species, and (c) at least one charged therapeutic agent, wherein said medical device is configured for implantation or insertion into a subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 30, 53, 54, 55, 56)
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10. (canceled)
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25. A medical device comprising a multilayer region, the multilayer region comprising:
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a) a charged nanoparticle layer comprising charged nanoparticles; and (b) a plurality of charged polyelectroyte layers comprising charged polyelectrolyte species, wherein one or more reinforcement members are provided adjacent to or within said multilayer region, said device is configured for implantation or insertion into a subject. - View Dependent Claims (26)
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27. A medical device comprising a multilayer region, the multilayer region comprising:
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a) a charged nanoparticle layer comprising charged nanoparticles; and (b) a plurality of charged polyelectroyte layers comprising charged polyelectrolyte species, the medical device further comprising a residue from a removable substrate adjacent said multilayer region.
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28. A medical device comprising a multilayer region, the multilayer region comprising:
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a) a charged nanoparticle layer comprising charged nanoparticles; and (b) a plurality of charged polyelectroyte layers comprising charged polyelectrolyte species, wherein charged nanocapsules, which comprise a plurality of charged polyelectrolyte encapsulation layers, are incorporated into said multilayer region. - View Dependent Claims (29)
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31-52. -52. (canceled)
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57. A medical device comprising a multilayer region, the multilayer region comprising:
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(a) a charged nanoparticle layer comprising charged nanoparticles; and (b) a plurality of charged polyelectroyte layers comprising charged polyelectrolyte species, wherein at least a portion of said multilayer region is free standing, and said medical device is configured for implantation or insertion into a subject.
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58. A medical device comprising a multilayer region that comprises:
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(a) a charged nanoparticle layer comprising charged nanoparticles; (b) a plurality of charged polyelectroyte layers comprising charged polyelectrolyte species, (c) at least one therapeutic agent, and (d) at least one protective coating is provided over at least a portion of the multilayer region, wherein said medical device is configured for implantation or insertion into a subject.
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59. A medical device comprising a multilayer region that comprises:
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(a) a charged nanoparticle layer comprising charged nanoparticles; (b) a plurality of charged polyelectroyte layers comprising charged polyelectrolyte species, and (c) one or more reinforcement members provided adjacent to or within said multilayer region, said reinforcement members are in the form of a fiber mesh, a fiber braid or fiber winding, wherein said medical device is configured for implantation or insertion into a subject.
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60. A medical device comprising a multilayer region that comprises:
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(a) a charged nanoparticle layer comprising charged nanoparticles; (b) a plurality of charged polyelectroyte layers comprising charged polyelectrolyte species, and (c) charged nanocapsules incorporated into said multilayer region, said charged nanocapsules comprise a therapeutic agent, wherein said medical device is configured for implantation or insertion into a subject.
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Specification