AEROSOL DELIVERY SYSTEM AND USES THEREOF
First Claim
1. A device for producing a condensation aerosol comprisinga chamber comprising an upstream opening and a downstream opening, the openings allowing gas to flow therethrougha heat-conductive substrate, the substrate located at a position between the upstream and downstream openings,a drug composition film on the substrate, the film comprising a therapeutically effective dose of a drug when the drug is administered in aerosol formheat source for supplying heat to said substrate to produce a substrate temperature greater than 300°
- C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less, and the device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
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Accused Products
Abstract
A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300 oC, and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
138 Citations
28 Claims
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1. A device for producing a condensation aerosol comprising
a chamber comprising an upstream opening and a downstream opening, the openings allowing gas to flow therethrough a heat-conductive substrate, the substrate located at a position between the upstream and downstream openings, a drug composition film on the substrate, the film comprising a therapeutically effective dose of a drug when the drug is administered in aerosol form heat source for supplying heat to said substrate to produce a substrate temperature greater than 300° - C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less, and the device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for producing a condensation aerosol comprising heating to a temperature greater than 300oC a heat-conductive substrate having a drug composition film on the surface, the film comprising a therapeutically effective dose of a drug when the drug is administered in aerosol form;
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substantially volatilizing the drug composition film from the substrate in a period of 2 seconds or less, and flowing air across the volatilized drug composition, under conditions to produce an aerosol containing less than 10% by weight drug composition degradation products and at least 50% of the drug composition in said film. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19)
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20. An assembly for use in a condensation aerosol device comprising
a heat-conductive substrate having an interior surface and an exterior surface; -
a drug composition film on the substrate exterior surface, the film comprising a therapeutically effective dose of a drug when the drug is administered in aerosol form, and a heat source for supplying heat to said substrate to produce a substrate temperature greater than 300oC and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28)
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Specification