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Mutated Netrin-4, Fragments Thereof And Their Use As Medicines

  • US 20100183588A1
  • Filed: 11/22/2005
  • Published: 07/22/2010
  • Est. Priority Date: 11/22/2004
  • Status: Active Grant
First Claim
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1. Protein comprising or being constituted by one of the following sequences:

  • the sequence SEQ ID NO;

    522 or SEQ ID NO;

    524, ora fragment of said sequence SEQ ID NO;

    522 or SEQ ID NO;

    524, providing that this fragment exhibits anti-angiogenic activity and/or pericyte activation activity, said fragment comprising 40 to 450 amino acids, and preferably 40 to 260 amino acids and preferably 40 to 230 amino acids, and being represented by one of the sequences SEQ ID NO;

    2q, q varying from 187 to 248, or by the sequence SEQ ID NO;

    526 or by the sequence SEQ ID NO;

    528,any sequence derived from one of the abovementioned sequences, by substitution, suppression or addition of one or more amino acids, providing that this derived sequence exhibits anti-angiogenic activity and/or pericyte activation activity, orany sequence homologous to one of the abovementioned sequences, preferably having at least 50% identity with the region comprised between the amino acids at position 261 and 515 of SEQ ID NO;

    522, providing that this homologous sequence exhibits anti-angiogenic activity and/or pericyte activation activity.

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