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Compositions and Methods for the Treatment of Cancer

  • US 20100183603A1
  • Filed: 06/19/2008
  • Published: 07/22/2010
  • Est. Priority Date: 06/22/2007
  • Status: Active Grant
First Claim
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1. A compound of formula Ia, Ib, IIa, or IIb, or a pharmaceutically acceptable salt thereof:

  • Where U is independently selected from;

    wherein;

    R1, R2, and R3 are independently selected from the group consisting of H, F, Cl, Br, I, —

    NR7R8, —

    (C1-C6)alkyl, —

    (C1-C6)substituted alkyl, —

    (C3-C9)cycloalkyl, —

    (C3-C9) substituted cycloalkyl, —

    O—

    (C1-C6) alkyl, —

    O—

    (C3-C9) cycloalkyl, and —

    O—

    (C3-C9) substituted cycloalkyl, aryl, heteroaryl, and heterocyclyl;

    R4, R7, and R8 are independently selected from the group consisting of H, —

    (C1-C4) alkyl, and —

    (C1-C4) substituted alkyl;

    R5 is selected from the group consisting of H, —

    (C1-C6) alkyl, and —

    CH2R6;

    R6 is selected from the group consisting of —

    O—

    P(═

    O)(OH)2, —

    O—

    P(═

    O)(—

    OH)(—

    O—

    (C1-C6) alkyl), —

    O—

    P(═

    O)(—

    O—

    (C1-C6) alkyl)2, —

    O—

    P(═

    O)(—

    OH) (—

    O—

    (CH2)-phenyl), —

    O—

    P(═

    O)(—

    O—

    (CH2)-phenyl)2, a carboxylic acid group, an amino carboxylic acid group, and a peptide;

    R9 is selected from the group consisting of H, —

    (C1-C6)alkyl, —

    (C1-C6)substituted alkyl, —

    (C3-C9)cycloalkyl, —

    (C3-C9) substituted cycloalkyl, aryl, heteroaryl, and heterocyclyl;

    Q is selected from the group consisting of aryl, heteroaryl, heterocyclyl, alkyl, substituted aryl, substituted heteroaryl, substituted heterocyclyl, and substituted alkyl;

    T is —

    CH2

    , —

    C(O)—

    , or a bond;

    when T is a bond, Y is a bond, W is bond, X is —

    CH2

    , and m=1, n=1;

    V and Z are independently selected from the group consisting of O, S, and H2;

    X is independently selected from the group consisting of —

    CH2

    , —

    NR8, S, O, and a bond;

    Y and W are independently —

    CH2

    , or a bond;

    m is 1 or 2;

    n is 1 or 2;

    and wherein X, Y, and W cannot all be a bond.

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