Method of Capturing and Macerating Particles in a Blood Vessel

• US 20100185210A1
• Filed: 03/29/2010
• Published: 07/22/2010
• Est. Priority Date: 03/25/2004
• Status: Active Grant

• Current Assignee: Inari Medical, Inc.
• Original Assignee: David L. Hauser, Pui Tong Ho
• Inventors: Hauser, David L., Ho, Pui Tong
• Granted Patent: US 8,252,020 B2
• Time in Patent Office: Days
• US Class Current: 606/128
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/225 for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
• CPC Class Codes: A61B 17/320758 with a rotating cutting instrument, e.g. motor driven A61B17/320725, A61B17/32075 and A61B17/320783 take precedence; for removing intra-ocular material A61F9/00763; endoscopic rotatable cutting instruments A61B17/32002
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61B 2017/320775 Morcellators, impeller or propeller like means
• CPC Class Codes: A61F 2/0105 Open ended, i.e. legs gathered only at one side
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/006 Y-shaped
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2230/0093 Umbrella-shaped, e.g. mushroom-shaped

Abstract

A method of capturing and macerating particles in a blood vessel is provided. A vascular filter device is implanted in the blood vessel at a treatment site. The vascular filter device comprises a filter body and an agitation member disposed within the filter body. Movement of the agitation member acts on particles trapped within the filter body for enhancing the dissolution of the particles, thereby reducing the likelihood of filter occlusion and improving the flow of blood through the vessel. The vascular filter device is preferably collapsible for percutaneous delivery to a treatment site. The agitation member is preferably rotatably coupled to the filter body. A power source is provided for moving the agitation member. In various examples, the power source may take the form of an energy storage device, a drive catheter, or a magnetic field.

Claims

1. A method of capturing and macerating particles in a blood vessel, comprising:

providing an implantable filter device along a distal end portion of a delivery catheter, the implantable filter device including a collapsible and expandable filter body and a rotatable agitation member coupled to the filter body;

advancing the implantable filter device through the blood vessel while the filter body is in a collapsed state;

expanding the filter body such that the filter body engages an inner wall of the blood vessel;

detaching the filter device from the delivery catheter; and

withdrawing the delivery catheter from the blood vessel while allowing the filter body and agitation member to remain in the blood vessel, wherein the agitation member is adapted to rotate relative to the filter body for breaking apart particles captured within the filter body.

2. The method of claim 1, wherein the rotatable agitation member is located substantially within an interior volume of the filter body.

3. The method of claim 1, wherein the filter device further comprises an electronic sensor for detecting the presence of particles captured within the filter body.

4. The method of claim 1, wherein the filter device further comprises an energy storage device coupled to the agitation member for causing the agitation member to rotate relative to the filter body.

5. The method of claim 4, wherein the energy storage device is a battery.

6. The method of claim 1, wherein the rotatable agitation member is configured to be rotated by an energy source located outside the patient'"'"'s body.

7. The method of claim 6, wherein the energy source is a variable magnetic field.

8. The method of claim 1, wherein the filter body has a substantially conical shape.

9. The method of claim 1, further comprising advancing an elongate drive mechanism through the blood vessel to the implantable filter device, the elongate drive mechanism adapted to temporarily contact and mechanically engage the agitation member, and causing the agitation member to rotate relative to the filter body.

10. The method of claim 9, further comprising advancing an aspiration catheter over the elongate drive mechanism.

11. A method of capturing and macerating particles in a blood vessel, comprising:

securing an implantable filter device to a distal end portion of a delivery catheter, the implantable filter device including a collapsible and expandable filter body and an agitation member coupled to the filter body and an energy storage device coupled to the agitation member;

advancing the implantable filter device through the blood vessel while the filter body is in a collapsed state;

expanding the filter body such that the filter body engages an inner wall of the blood vessel; and

withdrawing the delivery catheter from the blood vessel while allowing the filter device to remain in the blood vessel;

wherein the energy storage device is adapted to cause the agitation member to move relative to the filter body for breaking apart particles captured within the filter body.

12. The method of claim 11, wherein the energy storage device is a battery.

13. The method of claim 11, wherein the filter device further comprises an electronic sensor for detecting the presence of particles captured within the filter body.

14. The method of claim 11, wherein the agitation member is located substantially within an interior volume of the filter body.

15. The method of claim 14, wherein the filter body has a substantially conical shape.

16. The method of claim 11, wherein the agitation member is configured to vibrate for breaking apart captured particles.

17. The method of claim 16, wherein the agitation member is configured to vibrate at ultrasonic frequencies.

18. The method of claim 17, further comprising delivering a thrombolytic drug into the blood vessel for enhancing the dissolution of captured particles.

19. The method of claim 11, wherein the blood vessel is a coronary artery.

20. A method of dissolving a thrombus in a blood vessel for improving blood flow through the blood vessel, comprising:

providing a filter device comprising an expandable filter body permanently fixed to a distal end portion of an outer catheter and a rotatable agitation member disposed along a distal end portion of an inner catheter, wherein the inner catheter is slidably and rotatably contained within the outer catheter;

expanding the expandable filter body in the blood vessel;

distally advancing the inner catheter relative to the outer catheter such that the agitation member is positioned distal to the filter body at a treatment site;

rotating the agitation member for dissolving the thrombus in the blood vessel;

applying aspiration for pulling resulting particles into the filter body;

retracting the filter device into a delivery sheath with the particles captured inside the filter body; and

withdrawing the filter device and delivery sheath from the blood vessel.