APPARATUS AND METHODS FOR CONTROLLED ISCHEMIC CONDITIONING
First Claim
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1. An instrument for inducing ischemic conditioning by controlled extravascular occlusion, comprising:
- at least one occluding member adapted to partially or completely surround at least one blood vessel, anda controller operably connected to the at least one occluding member, wherein the controller is adapted to remotely control occlusion and release of the blood vessel by the at least one occluding member.
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Abstract
Methods and apparatus for ischemic conditioning treatment in a patient are provided. Transient ischemia is caused by interrupting blood flow to a tissue. Markers of ischemia and metabolism are monitored in the tissue and the induced ischemia is adjusted based on the monitoring results.
79 Citations
37 Claims
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1. An instrument for inducing ischemic conditioning by controlled extravascular occlusion, comprising:
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at least one occluding member adapted to partially or completely surround at least one blood vessel, and a controller operably connected to the at least one occluding member, wherein the controller is adapted to remotely control occlusion and release of the blood vessel by the at least one occluding member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An instrument for inducing ischemic conditioning in a tissue by controlled intravascular occlusion of one or more blood vessels feeding the tissue, comprising:
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an occluding member; a sensor disposed distal to the occluding member and adapted to detect one or more of;
markers of ischemia or metabolism, and combinations thereof in the tissue; anda programmable controller operably connected to the occluding member and the sensor and adapted to control the occlusion and release of the blood vessel by the occluding member based on the sensed markers. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for ischemic conditioning in a patient using an extravascular occlusion, comprising:
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guiding an occluding instrument having at least one interior space to a blood vessel of the patient, positioning the occluding instrument around the blood vessel, compressing the blood vessel with the occluding instrument to induce at least a partial occlusion, decompressing the blood vessel to at least a partial release, and remotely controlling the occlusion and decompressing by the occluding instrument. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31)
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32. A method for intravascular occlusion in a patient comprising:
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guiding an instrument to a blood vessel in the patient, positioning the instrument to contact the blood vessel at an occlusion site, causing ischemia by interrupting blood flow to a tissue distal to the occlusion site, monitoring markers of ischemia and/or metabolism in the tissue distal to the occlusion site, and adjusting the ischemia based on the monitoring results.
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- 33. A method for preventing, minimizing, or reducing reperfusion injury by controlling reperfusion to a target tissue based on measurements of metabolic markers of ischemia in the target tissue.
Specification