Vacuum-Assisted Microscale Cutting Device

• US 20100185222A1
• Filed: 08/13/2007
• Published: 07/22/2010
• Est. Priority Date: 08/11/2006
• Status: Abandoned Application

• Current Assignee: Mynosys Cellular Devices, Inc.
• Original Assignee: Mynosys Cellular Devices, Inc.
• Inventors: Keller, Christopher Guild
• Application Number:
  US12/377,228
• Publication Number:
  US 20100185222A1
• Time in Patent Office: Days
• US Class Current: 606/170
• CPC Class Codes: A61B 17/32 Surgical cutting instruments A61B18/042 takes precedence; suture cutters A61B17/0467; instruments for ligaturing or cutting A61B17/128; instruments for rupturing the amniotic membrane A61B17/4208; specially adapted knives for eye surgery A61F9/0133
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 17/3211 Surgical scalpels, knives; Accessories therefor
• CPC Class Codes: A61B 2017/00345 Micromachines, nanomachines, microsystems
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/0088 ceramic

Abstract

A vacuum-assisted microscale cutting instrument applies a vacuum pressure to pull an area of tissue towards a microknife. The cutting instrument can be configured to make one or more stabbing cuts or a slicing cut, and the housing of the instrument is shaped to address any of a variety of tissue geometries to allow a vacuum seal to be created therewith. To achieve a consistent cut depth in the tissue, a depth stop may be used to prevent the knife from cutting deeper than a predetermined depth.

Claims

1. A microscale cutting device comprising:

a housing defining a vacuum chamber within the housing;

a microknife mounted within the vacuum chamber of the housing;

a vacuum connector in communication with the vacuum chamber and adapted to be coupled to a vacuum source for creating a vacuum pressure within the housing.

2. The device of claim 1, further comprising:

a depth stop fixed to the device in relation to the microknife, the depth stop preventing a cut by the microknife beyond a predetermined maximum depth.

3. The device of claim 1, wherein the housing is shaped to fit over a planar tissue surface to enclose the vacuum chamber.

4. The device of claim 1, wherein the housing is shaped to fit over a cylindrical tissue surface to enclose the vacuum chamber.

5. The device of claim 1, wherein the housing is shaped to fit over a spherical tissue surface to enclose the vacuum chamber.

6. The device of claim 1, wherein the housing is shaped to fit over a concave tissue surface to enclose the vacuum chamber.

7. The device of claim 1, wherein the housing is shaped to fit over an irregular tissue surface to enclose the vacuum chamber.

8. The device of claim 1, wherein the housing is shaped to fit within a tubular structure to enclose the vacuum chamber.

9. The device of claim 1, wherein the microknife is coupled to an actuator configured to move the microknife towards a tissue surface when the housing is placed over tissue, thereby making a stab cut into the tissue.

10. The device of claim 1, wherein the microknife is coupled to an actuator configured to move the microknife in a direction transverse to a tissue surface when the housing is placed over tissue, thereby making a slice cut in the tissue.

11. The device of claim 10, wherein the microknife is curved for making a strip cut through a section of tissue.

12. The device of claim 1, further comprising:

an air valve pneumatically coupling the vacuum chamber to an ambient atmosphere;

a vacuum valve pneumatically coupling the vacuum chamber to a vacuum source; and

a valve controller operably coupled to open and close individually the air valve and the vacuum valve.

13. The device of claim 1, further comprising:

an internal pneumatic actuator coupled to the vacuum chamber; and

an external pneumatic actuator coupled to an atmosphere outside the vacuum chamber;

where the internal pneumatic actuator and external pneumatic actuator are coupled to opposing side of the vacuum chamber and the microknife coupled therebetween, wherein a lower pressure applied to the vacuum chamber relative to an atmospheric pressure causes contraction of the internal pneumatic actuator, expansion of the external pneumatic actuator, and resulting translation of the microknife.

14. The device of claim 13, wherein the internal pneumatic actuator and the external pneumatic actuator each comprise a bellows.

15. The device of claim 1, further comprising:

a pneumatic actuator coupling the microknife within the vacuum chamber, wherein a lower pressure applied to the vacuum chamber relative to an atmospheric pressure causes expansion of the pneumatic actuator and translation of the microknife.

16. The device of claim 1, wherein the housing is compliant such that a lower pressure applied to the vacuum chamber relative to an atmospheric pressure causes a deflection of the housing and translation of the microknife.

17. The device of claim 1, further comprising:

a handle; and

a linear actuator operably coupled to the microknife for pulling the microknife over a length of tissue.

18. The device of claim 1, further comprising:

a vacuum source coupled to the vacuum connector of the microscale cutting device and configured to create a vacuum pressure within the housing.

19. A device for performing a microscale operation on tissue, the device comprising:

a housing defining a vacuum chamber within the housing and configured to be placed over an area of tissue;

a vacuum connector in communication with the vacuum chamber and adapted to be coupled to a vacuum source for creating a vacuum pressure within the housing; and

a surgical tool mounted within the vacuum chamber of the housing.

20. The device of claim 19 wherein the surgical tool is mounted to the housing by a pneumatic actuator so that, upon application of a vacuum pressure within the housing, the pneumatic actuator expands to move the surgical tool.

21. The device of claim 20, wherein the pneumatic actuator comprises a bellows.

22. The device of claim 19, wherein the surgical tool is a needle.

23. The device of claim 22, further comprising:

a liquid-filled capsule in communication with the needle.

24. The device of claim 23, wherein the liquid-filled capsule is filled with a therapeutic agent.

25. The device of claim 23, further comprising:

a pneumatic actuator coupled between the housing and the needle, wherein upon application of a vacuum pressure within the housing when the device is placed adjacent to an area of tissue, the pneumatic actuator is configured to move the needle into the tissue and press against the liquid-filled capsule to force the liquid through the needle and into the tissue.

26. The device of claim 22, further comprising:

a guiding collar mounted around the needle to constrain the motion of the needle in one or more dimensions.

27. The device of claim 22, wherein the device is mounted within a catheter to allow injection from within a tubular structure.

28. A method for performing microscale cutting, the method comprising:

placing a housing of a microscale cutting device against an area of tissue to be treated to create a vacuum seal with the tissue, wherein the cutting device comprises a microknife mounted within the housing;

reducing the pressure within the housing of the microscale cutting device relative to outside the housing, thereby causing a portion of the tissue to tend to be forced toward the housing; and

cutting into the tissue with the microknife.

29. The method of claim 28, wherein the cutting comprises maintaining a consistent depth of cut using a depth stop fixed to the device in relation to the microknife.

30. The method of claim 28, wherein the area of tissue is planar and the housing is shaped to fit thereover to form the vacuum seal.

31. The method of claim 28, wherein the area of tissue is cylindrical and the housing is shaped to fit thereover to form the vacuum seal.

32. The method of claim 28 wherein the area of tissue is spherical and the housing is shaped to fit thereover to form the vacuum seal.

33. The method of claim 28, wherein the housing is shaped to fit over a concave tissue surface to enclose the vacuum chamber.

34. The method of claim 28, wherein the housing is shaped to fit over an irregular tissue surface to enclose the vacuum chamber.

35. The method of claim 28, wherein the housing is shaped to fit within a tubular structure to enclose the vacuum chamber.

36. The method of claim 28, wherein the cutting comprises:

actuating the microknife in an alternating fashion into and out of the tissue to create a series of stab cuts in the tissue; and

moving the microscale cutting device along the tissue.

37. The method of claim 36, wherein the microscale cutting device is moved at a rate no greater than half of the width of a single stab for each stab cut made.

38. The method of claim 28, wherein the cutting comprises:

raising the tissue surface by reducing the pressure within the housing; and

actuating the microknife in a direction transverse to the tissue surface and through a section of the tissue to create a slice cut in the tissue.

39. The method of claim 38, wherein the microknife is curved for making a strip cut through a section of tissue.

40. The method of claim 38, wherein actuating the microknife in a direction transverse to the tissue surface comprises:

contracting an internal pneumatic actuator and expanding an external pneumatic actuator by reducing the pressure in the housing, where the internal pneumatic actuator and external pneumatic actuator are coupled to opposing side of the vacuum chamber and the microknife coupled therebetween.

41. The method of claim 40, wherein the external pneumatic actuator and the internal pneumatic actuator each comprise a bellows.

42. The method of claim 28, wherein the cutting comprises:

expanding a pneumatic actuator by reducing the pressure in the housing to cause translation of the microknife.

43. The method of claim 42, wherein the pneumatic actuator comprises a bellows.

44. The method of claim 28, wherein the cutting comprises:

deflecting the housing of the device by reducing the pressure in the housing, where the deflection of the housing causes translation of the microknife.

45. The method of claim 28, wherein the cutting comprises:

move the microknife into the tissue; and

pulling the microknife over a length of tissue.

46. The method of claim 45, wherein the pulling the microknife comprises:

activating a linear actuator operably coupled to the microknife to pull thereon.