BAROREFLEX STIMULATION SYNCHRONIZED TO CIRCADIAN RHYTHM
First Claim
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1. A method for operating an implantable medical device, comprising:
- applying a baroreflex stimulation therapy at a stimulation intensity using a baroreflex stimulator in the implantable medical device; and
modulating the baroreflex stimulation therapy based on a circadian rhythm template stored within the implantable medical device, wherein modulating the baroreflex stimulation therapy includes using the circadian rhythm template to change the stimulation intensity to mimic natural blood pressure fluctuations during the day.
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Abstract
An aspect relates to a baroreflex stimulator. An embodiment of the stimulator comprises a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm template.
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Citations
20 Claims
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1. A method for operating an implantable medical device, comprising:
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applying a baroreflex stimulation therapy at a stimulation intensity using a baroreflex stimulator in the implantable medical device; and modulating the baroreflex stimulation therapy based on a circadian rhythm template stored within the implantable medical device, wherein modulating the baroreflex stimulation therapy includes using the circadian rhythm template to change the stimulation intensity to mimic natural blood pressure fluctuations during the day. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for treating hypertension, comprising:
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accessing a circadian rhythm template; setting a baroreflex stimulation level based on the circadian rhythm template; and applying baroreflex stimulation at the baroreflex stimulation level to a baroreceptor site in a pulmonary artery. - View Dependent Claims (18, 19)
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20. A baroreflex stimulator, comprising:
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a pulse generator adapted to deliver a baroreflex stimulation therapy using a baroreflex stimulation signal; and means for modulating the baroreflex stimulation signal based on a circadian rhythm template to mimic natural blood pressure fluctuations during the day, wherein the circadian rhythm template includes a mean arterial pressure template, a stroke volume template, a cardiac output template, or a total peripheral resistance template.
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Specification