Nanorough Alloy Substrate

• US 20100185294A1
• Filed: 02/23/2010
• Published: 07/22/2010
• Est. Priority Date: 06/04/2002
• Status: Abandoned Application

• Current Assignee: Arthrosurface, Inc (Anika Therapeutics Incorporated)
• Original Assignee: Arthrosurface, Inc (Anika Therapeutics Incorporated)
• Inventors: Ek, Steven W.
• Application Number:
  US12/711,039
• Publication Number:
  US 20100185294A1
• Time in Patent Office: Days
• US Class Current: 623/18.110
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/3859 Femoral components
• CPC Class Codes: A61F 2002/30299 umbrella-shaped or mushroom-shaped
• CPC Class Codes: A61F 2002/3084 Nanostructures
• CPC Class Codes: A61F 2002/3085 with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface
• CPC Class Codes: A61F 2002/30925 etched
• CPC Class Codes: A61F 2230/0093 Umbrella-shaped, e.g. mushroom-shaped
• CPC Class Codes: A61F 2310/00029 Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium

Abstract

A CoCr substrate for growing mammalian cells and, in particular, chondrocytes and synovial stem cells. The substrate may be treated electrolytically to produce a surface topography that is amenable to cell growth and migration. The substrate shows improved adhesion and migration characteristics and may be useful as a prosthesis or implant and in particular as a prosthesis in a joint such as the knee.

Claims

1. A joint prosthesis comprising:

a first surface having a curvature that substantially matches the contour of native articular surface, said first surface comprising a cobalt chromium alloy having an average surface feature size of between 10 and 30 nm.

2. The prosthesis of claim 1 wherein the first surface comprises features that are substantially spherical and about 20 nm in size.

3. The prosthesis of claim 1 further comprising a layer of mammalian cells on the first surface.

4. The prosthesis of claim 1 further comprising a layer of human chondrocytes on the first surface.

5. The prosthesis of claim 1 wherein the prosthesis is affixed to bone tissue in a human patient.

6. The prosthesis of claim 1 wherein human cartilage is affixed to the first surface.

7. The prosthesis of claim 6 wherein the alloy further comprises molybdenum.

8. The prosthesis of claim 1 wherein the prosthesis is a knee prosthesis.

9. A prosthesis for supporting the growth of mammalian cells, the prosthesis comprising a cobalt chromium alloy surface having a surface energy of greater than 30 mJ/m².

10. The prosthesis of claim 9 wherein human chondrocytes are disposed on the surface.

11. The prosthesis of claim 9 further comprising molybdenum.

12. The prosthesis of claim 9 having a portion consisting essentially of a cobalt chromium alloy.

13. The prosthesis of claim 9 having a portion consisting essentially of a cobalt chromium alloy doped with molybdenum.

14. The prosthesis of claim 9 comprising a screw for insertion into bone.

15. The prosthesis of claim 14 comprising a first portion including a contoured surface of cobalt chromium alloy and a second portion including a titanium screw.

16. A prosthesis for supporting mammalian cells, the prosthesis comprising a contoured surface comprising a cobalt chromium alloy exhibiting a wet contact angle of less than about 60 degrees.

17. The prosthesis of claim 16 wherein the wet contact angle is less than about 45 degrees.

18. The prosthesis of claim 16 wherein the wet contact angle is less than about 20 degrees.