Device for Delivering Medicament

• US 20100186739A1
• Filed: 05/22/2006
• Published: 07/29/2010
• Est. Priority Date: 06/01/2005
• Status: Active Grant

• Current Assignee: Shl Medical AG
• Original Assignee: SHL Group AB
• Inventors: Karlsson, Anders, Deurrell, Tomas, Brunnberg, Lennart, Olson, Stephan, Kronestedt, Victor
• Granted Patent: US 8,617,109 B2
• Time in Patent Office: Days
• US Class Current: 128/203.120
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/0073 on a ring
• CPC Class Codes: A61M 15/0076 on a drum
• CPC Class Codes: A61M 15/0081 Locking means
• CPC Class Codes: A61M 15/0083 Timers
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/202 cocking means, e.g. to bias the main drive spring of an injector
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2202/0468 non-physiological
• CPC Class Codes: A61M 2205/585 having magnification means, e.g. magnifying glasses
• CPC Class Codes: A61M 2205/8281 spring operated
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 2210/0618 Nose
• CPC Class Codes: A61M 2210/0625 Mouth
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 : Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/2448 : comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3146 : Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31535 : Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31551 : including axial movement of dose setting member
• CPC Class Codes: A61M 5/31553 : without axial movement of dose setting member
• CPC Class Codes: A61M 5/31556 : Accuracy improving means
• CPC Class Codes: A61M 5/3156 : using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/31573 : Accuracy improving means
• CPC Class Codes: A61M 5/31583 : based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
• CPC Class Codes: A61M 5/31593 : Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/484 : Regulating injection pressure

Abstract

The present invention relates to a device for the delivery of predetermined doses of liquid medicament to a patient, which medicament is intended to be inhaled by the patient or intended to be injected into the body of the patient. The device is adapted to be in a medicament delivery state and in a medicament non-delivery state. When the device is in a medicament delivery state, said device is adapted to drive a piston into a cartridge containing the liquid medicament to be delivered, with a force that is above or equal to a predetermined minimum force value and below a predetermined maximum force value. The minimum force value is the lowest force value needed to deliver the predetermined dose and the maximum force value is the first force value at which it exists a risk of damaging the cartridge or the components of the device. Further, more of the spring force is brought to an efficient output torque ensuring that a predetermined volume of medicament is expelled from a cartridge.

Claims

1-12. -12. (canceled)

13. A device for delivering predetermined doses of liquid medicament, the device having a medicament delivery state and a medicament non-delivery state and comprising:

a cartridge configured to contain the liquid medicament and a piston sealingly and slidably arranged in the cartridge;

an energy accumulating member configured to stepwise accumulate energy when the device is in the medicament non-delivery state;

an elongated threaded plunger rod arranged in an interior of the device;

a plunger rod driving member configured to engage the threaded plunger rod and be in a driven state when the device is in the medicament delivery state and in a non-driven state when the device is in the medicament non-delivery state, wherein rotation of the plunger rod driving member due to output torque of the energy accumulating member drives the threaded plunger rod, enabling the threaded plunger rod, which is in contact with the piston, to be driven toward a proximal end of the cartridge by a predetermined distance and expel a predetermined dose of the liquid medicament from the cartridge; and

a bearing coupled to an outer cover and configured to pick up forces acting on a proximal part of the device in a longitudinal direction thereof, whereby more of the accumulated energy that results from stepwise rotational tensioning of the energy accumulating member positioned at a distal end of the device is converted to output torque.

14. The device of claim 13, wherein the energy accumulating member is a flat spiral spring.

15. The device of claim 13, further comprising a cartridge housing coupled to the outer cover, wherein an interior part of the cartridge housing engages a longitudinal extending device on the plunger rod, and an interior part of the plunger rod driving member engages the plunger rod with a thread that corresponds to a thread on the plunger rod, so that rotation of the plunger rod driving member drives the plunger rod toward the proximal end of the cartridge by the predetermined distance without rotation.

16. The device of claim 14, further comprising a cartridge housing coupled to the outer cover, wherein an interior part of the cartridge housing engages a longitudinal extending device on the plunger rod, and an interior part of the plunger rod driving member engages the plunger rod with a thread that corresponds to a thread on the plunger rod, so that rotation of the plunger rod driving member drives the plunger rod toward the proximal end of the cartridge by the predetermined distance without rotation.

17. The device of claim 13, wherein an interior part of the plunger rod driving member includes a device that engages a longitudinal extending device on the plunger rod, and an interior part of the bearing includes a thread that corresponds to a thread on the plunger rod, so that the plunger rod moves toward the proximal end of the cartridge by the predetermined distance with rotation.

18. The device of claim 14, wherein an interior part of the plunger rod driving member includes a device that engages a longitudinal extending device on the plunger rod, and an interior part of the bearing includes a thread that corresponds to a thread on the plunger rod, so that the plunger rod moves toward the proximal end of the cartridge by the predetermined distance with rotation.

19. The device of claim 13, further comprising a dose setting member configured to rotate stepwise when the device is in the medicament non-delivery state for stepwise increasing the accumulated energy in the energy accumulating member and to be pulled toward a distal end of the device to release the accumulated energy in the energy accumulating member for cancelling a dose.

20. The device of claim 13, wherein a proximal part of an exterior part of the plunger rod driving member includes outwardly protruding flanges configured to engage an inwardly protruding stopper provided on an interior part of an actuation sleeve when the device is in the medicament non-delivery state.

21. The device of claim 20, wherein the outwardly protruding flanges include a plurality of dose step protrusions equally distributed along a circumference of the proximal part of the plunger rod driving member so that every dose step delivers the same amount of medicament.

22. The device of claim 13, wherein the device during medicament delivery is configured to be set in the medicament non-delivery state before an entire set dose has been delivered, whereupon the plunger rod stops its movement toward the proximal end of the cartridge, and the device thereafter is configured to be set in the medicament delivery state, whereupon the plunger rod continues to move the predetermined distance towards the proximal end of the device.

23. The device of claim 13, wherein the device is configured to be connected to a medicament administering member that is put in a patient'"'"'s mouth or nose, whereby the predetermined dose of medicament is inhaled by the patient when the delivery device is in the medicament delivery state.

24. The device of claim 13, wherein the device is configured to be connected to a medicament administering member such that the predetermined dose of medicament is sprayed into an eye or onto a skin of a patient when the delivery device is in the medicament delivery state.

25. The device of claim 13, wherein the device is configured to be connected to a medicament administering member that delivers the predetermined dose of medicament as at least one drop when the delivery device is in the medicament delivery state.

26. The device of claim 13, wherein the device is configured to be connected to a medicament administering needle for injecting the predetermined dose of medicament into a body of a patient when the delivery device is in the medicament delivery state.