Heavy Ion Therapy with Microbeams
First Claim
1. A method for delivering therapeutic heavy ion radiation to a subject comprising the step of delivering a therapeutic dose of heavy ions substantially only to a target volume within the subject by generating a broad field of radiation effect substantially only within the target volume, the broad field of radiation effect not being generated in non-targeted tissue of the subject, said delivering comprising irradiating the target volume with at least two arrays of heavy ion microbeams, the at least two arrays each having at least two parallel, spatially distinct heavy ion microbeams, and wherein the step of delivering the microbeams further includes the step of interleaving the at least two arrays substantially only within the target volume to form a substantially continuous broad beam of radiation substantially only within the target volume.
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Accused Products
Abstract
A method for delivering therapeutic heavy ion radiation to a subject, wherein a therapeutic dose of heavy ions is delivered substantially only to a target volume within the subject by generating a broad field of radiation effect substantially only within the target volume, and wherein the broad field of radiation effect is not generated in non-targeted tissue. The method includes the step of irradiating the target volume with at least two arrays of heavy ion microbeams, wherein the at least two arrays each have at least two parallel, spatially distinct heavy ion microbeams. The two arrays of microbeams are interleaved substantially only within the target volume to form a substantially continuous broad beam of radiation substantially only within the target volume.
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Citations
20 Claims
- 1. A method for delivering therapeutic heavy ion radiation to a subject comprising the step of delivering a therapeutic dose of heavy ions substantially only to a target volume within the subject by generating a broad field of radiation effect substantially only within the target volume, the broad field of radiation effect not being generated in non-targeted tissue of the subject, said delivering comprising irradiating the target volume with at least two arrays of heavy ion microbeams, the at least two arrays each having at least two parallel, spatially distinct heavy ion microbeams, and wherein the step of delivering the microbeams further includes the step of interleaving the at least two arrays substantially only within the target volume to form a substantially continuous broad beam of radiation substantially only within the target volume.
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19. A method for delivering therapeutic heavy ion radiation to a subject comprising the steps of:
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delivering a first microbeam of heavy ions to the subject from a single fixed beam line, the microbeam having a beam thickness, a beam width and a beam plane defined by said beam width; rotating the subject about an axis perpendicular to the beam plane; translating the subject in a direction perpendicular to the beam plane by a distance substantially equal to or greater than half the beam spacing on-center; and delivering a second microbeam of heavy ions to the subject from the fixed beam line.
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20. A method for delivering therapeutic heavy ion radiation to a subject comprising the step of placing a multi-slit collimator made of a heavy metal in the path of an incident broad-beam of heavy ions coming from an accelerator, said collimator having a plurality of slits sized to produce a desired individual incident microbeam thickness.
Specification