SPUTUM DISSOLVING SUCTIONING SOLUTION FOR ENDOTRACHEAL AND TRACHEOSTOMY TUBES

• US 20100189808A1
• Filed: 01/26/2010
• Published: 07/29/2010
• Est. Priority Date: 01/27/2009
• Status: Active Grant

• Current Assignee: Teleflex Medical Incorporated (Teleflex Incorporated)
• Original Assignee: Teleflex Medical Incorporated (Teleflex Incorporated)
• Inventors: Peters, Erin, Rosenblatt, Joel, Gupta, Nisha
• Granted Patent: US 8,691,286 B2
• Time in Patent Office: Days
• US Class Current: 424/616
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/737 Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate A61K31/727 takes precedence
• CPC Class Codes: A61K 33/14 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0434 Cuffs
• CPC Class Codes: A61M 16/0463 combined with suction tubes, catheters or the like; Outside connections
• CPC Class Codes: A61M 16/0465 Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
• CPC Class Codes: A61M 2205/0222 Materials for reducing friction
• CPC Class Codes: A61M 2209/06 Packaging for specific medical equipment
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/10 Expectorants
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

A composition for dissolving or reducing the viscosity of sputum on a surface of a device includes an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution. The effective amount of glycerol is between about 30-50% and the effective amount of dextran sulfate is between about 10-30%. The composition may further include an antimicrobial agent.

Claims

1. A composition for dissolving or reducing the viscosity of sputum on a surface of a device, the composition comprising:

an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution.

2. The composition according to claim 1, wherein the effective amount of glycerol is between about 30-50%.

3. The composition according to claim 1, wherein the effective amount of dextran sulfate is between about 10-30%.

4. The composition according to claim 1, wherein the saline solution is at least about 0.85%.

5. The composition according to claim 1, wherein the effective amount of glycerol is about 40% and the effective amount of dextran sulfate is about 20%.

6. The composition according to claim 1, wherein the saline solution is at least about 0.5%.

7. The composition according to claim 1, further comprising one or more antimicrobial agents.

8. The composition according to claim 7, wherein the antimicrobial agent is selected from a group consisting of a taurinamide derivative, a phenol, quaternary ammonium surfactant, chlorine-containing, quinoline, quinaldinium, lactone, dye, thiosemicarbazone, quinone, sulfa, carbamates, urea, salicylamide, carbanilide, amide, guanide, amidine, chelate, imidazoline biocides, acetic acid, benzoic acid, sorbic acid, propionic acid, boric acid, dehydroacetic acid, sulfurous acid, vanillic acid, esters of p-hydroxybenzoic acid, ethanol, isopropanol, propylene glycol, benzyl alcohol, chlorobutanol, phenylethyl alcohol, 2-bromo-2-nitropropan-1,3-diol, formaldehyde, glutaraldehyde, calcium hypochlorite, potassium hypochlorite, sodium hypochlorite, iodine (in various solvents), povidone-iodine, hexamethylenetetramine, noxythiolin, 1-(3-choroallyl)-3,5,7-triazo 1-azoniaadamantane chloride, taurolidine, taurultam, EDTA, N(5-nitro-2-furfurylidene)-1-amino-hydantoin, 5-nitro-2-furaldehyde semicarbazone, 3,4,4′

-trichlorocarbanilide, 3,4′

,5-tribromosalicylanilide, salicylanilide, 3-trifluoromethyl-4,4′

-dichlorocarbanilide, 8-hydroxyquinoline, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarb oxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, hydrogen peroxide, peracetic acid, phenol, sodium oxychlorosene, parachlorometaxylenol, 2,4,4′

-trichloro-2′

-hydroxydiphenol, thymol, chlorhexidine, benzalkonium chloride, cetylpyridinium chloride, silver, nanosilver, silver sulfadiazine, silver nitrate, 5 fluorouracil, phenolic antiseptics, gentian violet, methylene blue, brilliant green, and bismuth compounds.

9. The composition according to claim 7, wherein the one or more antimicrobial agents includes a mixture of Iodine and potassium iodide.

10. The composition according to claim 9, wherein the mixture of Iodine and potassium iodide is at a ratio of 1:

2.

11. The composition according to claim 1, wherein the device is an endotracheal tube or a tracheostomy tube.

12. A method for removing mucus from a surface of a device inside a trachea, comprising:

applying a composition to the surface of the device to dissolve the mucus, the composition including an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution;

allowing the mucus to dissolve; and

removing the mucus from the trachea.

13. The method according to claim 12, wherein the effective amount of glycerol is between about 30-50%.

14. The method according to claim 12, wherein the effective amount of dextran sulfate is between about 10-30%.

15. The method according to claim 12, wherein the saline solution is at least about 0.85%.

16. The method according to claim 12, wherein the effective amount of glycerol is about 40% and the effective amount of dextran sulfate is about 20%.

17. The method according to claim 12, wherein the saline solution is at least about 0.5%.

18. The method according to claim 12, further comprising one or more antimicrobial agents.

19. The method according to claim 18, wherein the antimicrobial agent is selected from a group consisting of a taurinamide derivative, a phenol, quaternary ammonium surfactant, chlorine-containing, quinoline, quinaldinium, lactone, dye, thiosemicarbazone, quinone, sulfa, carbamates, urea, salicylamide, carbanilide, amide, guanide, amidine, chelate, imidazoline biocides, acetic acid, benzoic acid, sorbic acid, propionic acid, boric acid, dehydroacetic acid, sulfurous acid, vanillic acid, esters of p-hydroxybenzoic acid, ethanol, isopropanol, propylene glycol, benzyl alcohol, chlorobutanol, phenylethyl alcohol, 2-bromo-2-nitropropan-1,3-diol, formaldehyde, glutaraldehyde, calcium hypochlorite, potassium hypochlorite, sodium hypochlorite, iodine (in various solvents), povidone-iodine, hexamethylenetetramine, noxythiolin, 1-(3-choroallyl)-3,5,7-triazo 1-azoniaadamantane chloride, taurolidine, taurultam, EDTA, N(5-nitro-2-furfurylidene)-1-amino-hydantoin, 5-nitro-2-furaldehyde semicarbazone, 3,4,4′

-trichlorocarbanilide, 3,4′

,5-tribromosalicylanilide, salicylanilide, 3-trifluoromethyl-4,4′

-dichlorocarbanilide, 8-hydroxyquinoline, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarb oxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, hydrogen peroxide, peracetic acid, phenol, sodium oxychlorosene, parachlorometaxylenol, 2,4,4′

-trichloro-2′

-hydroxydiphenol, thymol, chlorhexidine, benzalkonium chloride, cetylpyridinium chloride, silver, nanosilver, silver sulfadiazine, silver nitrate, 5 fluorouracil, phenolic antiseptics, gentian violet, methylene blue, brilliant green, and bismuth compounds.

20. The method according to claim 18, wherein the one or more antimicrobial agents includes a mixture of Iodine and potassium iodide.

21. The method according to claim 20, wherein the mixture of Iodine and potassium iodide is at a ratio of 1:

2.

22. The method according to claim 12, wherein the device is an endotracheal tube or a tracheostomy tube.

23. A method for removing built-up sputum or mucus from a surface of a tracheal cuff tube or in a lumen of a tube inside a trachea of a patient, comprising:

applying a composition to the surface of the tracheal cuff tube or in the lumen of the tube to dissolve the built-up sputum or mucus, the composition including an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution;

allowing the built-up sputum or mucus to dissolve; and

suctioning the built-up sputum or mucus from the surface.

24. The method of claim 23, wherein the effective amount of glycerol is about 40%, the effective amount of dextran sulfate is about 20%, and the saline solution is about 0.85%.

25. A kit comprising:

a suctioning catheter; and

a sputum dissolving solution having an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution.

26. A VAP prevention kit comprising:

a sputum dissolving solution having an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution; and

oral prophylaxis items.

27. The VAP prevention kit according to claim 26, wherein the oral prophylaxis items includes at least a tooth brush, a swab, and disinfecting mouth rinse.