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GPR120 RECEPTOR AGONISTS AND USES THEREOF

  • US 20100190831A1
  • Filed: 12/17/2009
  • Published: 07/29/2010
  • Est. Priority Date: 12/18/2008
  • Status: Active Grant
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First Claim
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1. A compound of Formula (A) or a pharmaceutically acceptable salt thereof, wherein:

  • the group J is absent or selected from the group consisting the ring Q is selected from the group consisting of aryl, heteroaryl, wherein Q is optionally substituted with (R6)k;

    A1, A2, A3 and A4 are independently selected from the group consisting of N and C, with the proviso that only 0, 1 or 2 of A1, A2, A3 and A4 is N;

    T1, T2, T3 and T4 are independently selected from the group consisting of N, O, CR1 and CR1R2, with the proviso that only 0, 1 or 2 of T1, T2, T3 and T4 is selected from N and O;

    W1, W2, W3 and W4 are independently selected from the group consisting of N, NRa, CR1, CR1R2, O, S, S(O) and S(O)2, with the proviso that ring J is not 1,3-dioxolane;

    E1, E2 and E3 are independently selected from the group consisting of C and N;

    one of X and Y is a bond, —

    CH2—

    , —

    CHD-, or —

    CD2-, and the other of X and Y is selected from the group consisting of —

    CH2—

    , —

    CHD-, —

    CD2-, —

    C(O), —

    C(O)NRa, —

    NRa—

    , —

    O—

    , —

    S—

    , —

    S(O)— and

    —

    S(O)2—

    ;

    L is —

    (CR4R5)q—

    wherein optionally one —

    (CR4R5)—

    is replaced with —

    N—

    , —

    O—

    , —

    S—

    , —

    CR4═

    CR5—

    , or -phenyl-;

    G is selected from the group consisting of —

    C(O)OZ and —

    C(O)NZ2;

    each Z is independently selected from the group consisting of H, alkyl and substituted alkyl;

    each R1 and R2 is independently selected from the group consisting of H, deuterium, halo, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, oxo, alkoxy, substituted alkoxy, CN, —

    NRaRb, —

    C(O)Ra, —

    C(O)ORa, —

    C(O)NRaRb, —

    NRaC(O)Rb, —

    SRa, —

    S(O)Ra and —

    S(O)2Ra, and optionally R1 and R2 can cyclize to form a C3-7heterocyclyl, substituted C3-7heterocyclyl, spiro C3-7heterocyclyl, substituted spiro C3-7heterocyclyl, C3-7cycloalkyl, substituted C3-7cycloalkyl, spiroC3-7cycloalkyl or spiro substituted C3-7cycloalkyl;

    each R3 is independently selected from the group consisting of H, halo, alkyl, substituted alkyl, alkoxy, substituted alkoxy, —

    C(O)NRaRb, —

    NRaC(O)Rb, —

    NRaRb, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryloxy, substituted aryloxy and —

    CN;

    each R4 and R5 is independently selected from the group consisting H, deuterium, fluoro, alkyl, substituted alkyl, alkoxy and substituted alkoxy, and optionally R4 and R5 can cyclize to form a C3-7heterocyclyl, substituted C3-7heterocyclyl, spiro C3-7heterocyclyl, substituted spiro C3-7heterocyclyl, C3-7cycloalkyl, substituted C3-7cycloalkyl, spiroC3-7cycloalkyl or spiro substituted C3-7cycloalkyl;

    each R6 is independently selected from the group consisting of H, halo, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, CN, —

    ORa, —

    NRaRb, —

    C(O)Ra, —

    C(O)ORa, —

    C(O)NRaRb, —

    NRaC(O)Rb, —

    SRa, —

    S(O)Ra and —

    S(O)2Ra;

    each of Ra and Rb is independently selected from the group consisting of H, alkyl, substituted alkyl, cycloalkyl, heterocyclyl, substituted heterocyclyl, alkenyl, alkynyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl. the subscript k is 0, 1, 2 or 3;

    the subscript m is 0, 1, 2 or 3; and

    the subscript q is 0, 1, 2, 3 or 4.

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