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METHOD OF ELECTRICALLY DETECTING A BIOLOGICAL ANALYTE MOLECULE

  • US 20100194409A1
  • Filed: 08/14/2007
  • Published: 08/05/2010
  • Est. Priority Date: 08/16/2006
  • Status: Abandoned Application
First Claim
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1. A method of electrically detecting a biological analyte molecule by means of a pair of electrodes, wherein said electrodes are arranged at a distance from one another and wherein said pair of electrodes is arranged within a sensing zone, the method comprising:

  • (a) immobilising on an immobilisation unit a capture molecule, wherein the capture molecule has an affinity to the analyte molecule and is capable of forming a complex with the analyte molecule;

    (b) contacting the immobilisation unit with a solution suspected to comprise the analyte molecule;

    (c) allowing the analyte molecule to form a complex with the capture molecule;

    (d) adding an electrically conducting nanoparticulate tag, wherein the electrically conducting nanoparticulate tag comprises or consists of electrically conducting matter that is capable of chemically interacting with the analyte molecule, thereby allowing said electrically conducting nanoparticulate tag to associate to the complex formed between said capture molecule and said analyte molecule;

    (e) determining the presence of the analyte molecule based on an electrical characteristic of a region in the sensing zone, wherein the electrical characteristic is influenced by the electrically conducting nanoparticulate tag.

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