Angiogenesis Mechanism and Method, and Implantable Device

• US 20100196439A1
• Filed: 12/20/2007
• Published: 08/05/2010
• Est. Priority Date: 12/22/2006
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Chaffin, Kimberly A., Davies, Neil, Hamlen, Robert Cushing, Jolly, Matthew, McAndrew, Eamonn J., Fogt, Eric J., VanAntwerp, William P., Pakala, Syamasundar V., Beck, Michael Theodore, Koullick, Edouard A., Grovender, Eric A., Bezuidenhout, Deon, Zilla, Peter P., Bonnema, Kelvin, Fernandes, Brian C.A.
• Application Number:
  US12/520,035
• Publication Number:
  US 20100196439A1
• Time in Patent Office: Days
• US Class Current: 424/424
• CPC Class Codes: A61F 2/022 Artificial gland structures using bioreactors hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/426 Immunomodulating agents, i.e. cytokines, interleukins, interferons
• CPC Class Codes: A61L 2300/434 of enzymes
• CPC Class Codes: A61L 27/3616 Blood, e.g. platelet-rich plasma
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

Various methods and devices are provided for providing therapy to a living body. In one embodiment, an implanted permeable container has living cells provided therein, and various nutrients and/or agents are provided into the container to promote cell life.

Claims

1-90. -90. (canceled)

91. An assembly for providing a vascularized, implanted device, comprising:

an implantable container having an exterior wall portion and an interior wall portion, said exterior wall portion being permeable to materials of a greater size than said interior wall portion;

a source connected with the implantable container that provides growth factors to the container; and

said interior wall portion enabling the growth factors to pass therethrough to reach the exterior wall portion to facilitate vessel formation on the exterior wall portion, said interior wall portion preventing substantial vessel formation within confines defined thereby.

92-95. -95. (canceled)

96. An implantable device for providing therapy to a living body, comprising:

a container permeable to growth factors;

an agent source for providing at least one agent to the container, the agent source arranged to be in communication with the container through a conduit;

wherein a surface of at least one of the agent source, container, or conduit is coated with a growth factor composition.

97. The device of claim 96, wherein at least one growth factor is eluted from the surface coated with a growth factor composition and emitted to the body.

98. The device of claim 96, further comprising therapeutic living cells carried by the container, said living cells capable of generating cell products that are emitted from the permeable container to the living body.

99. The device of claim 98, further wherein the agent source provides at least one agent to the living cells carried by the container, wherein the agent enhances living conditions for cells.

100. The device of claim 97, wherein the surface is coated with a growth factor composition comprising VEGF, and VEGF is eluted from the surface and emitted to the body.

101. The device of claim 97, wherein the surface is coated with APGS and at least one growth factor is eluted from the surface and emitted to the body.

102. An implantable device for providing therapy to a living body, comprising:

a container permeable to growth factors;

an agent source for providing at least one agent to the container, the agent source arranged to be in communication with the container through a conduit, wherein a fluid stream passes through the container, the agent source, and the conduit; and

a polymer system in contact with the fluid stream, wherein the polymer system comprises a growth factor composition formed as part of the polymer system, so as to allow at least one growth factor to be eluted into the fluid stream;

wherein the polymer system is placed in the device to be in contact with the fluid stream.

103. The device of claim 102, wherein at least one growth factor is eluted from the polymer system and emitted to the body.

104. The device of claim 102, further comprising therapeutic living cells carried by the container, said living cells capable of generating cell products that are emitted from the permeable container to the living body.

105. The device of claim 104, further wherein the agent source provides at least one agent to the living cells carried by the container, wherein the agent enhances living conditions for cells.

106. The device of claim 103, wherein the polymer system comprises a growth factor composition comprising VEGF, and VEGF is eluted from the polymer system and emitted to the body.

107. The device of claim 103, wherein the polymer system comprises APGS and at least one growth factor is eluted from the polymer system and emitted to the body.