PROTEIN MATRIX MATERIALS, DEVICES AND METHODS OF MAKING AND USING THEREOF
First Claim
1. A tissue graft comprising one or more biocompatible protein materials, combined with one or more biocompatible solvents, wherein the protein material(s) and biocompatible solvent(s) are formed into a cohesive body having a solvent content of about 20% to 80% prior to compression and the cohesive body is compressed at a pressure of about 100 psi to 100,000 psi to remove bulk biocompatible solvent and generate additional intermolecular and intramolecular forces between one or more of the protein material(s) and solvent(s) to form the tissue graft having a solvent content of about 10% to 60%.
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Accused Products
Abstract
The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.
130 Citations
43 Claims
- 1. A tissue graft comprising one or more biocompatible protein materials, combined with one or more biocompatible solvents, wherein the protein material(s) and biocompatible solvent(s) are formed into a cohesive body having a solvent content of about 20% to 80% prior to compression and the cohesive body is compressed at a pressure of about 100 psi to 100,000 psi to remove bulk biocompatible solvent and generate additional intermolecular and intramolecular forces between one or more of the protein material(s) and solvent(s) to form the tissue graft having a solvent content of about 10% to 60%.
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16. A method of replacing damaged, diseased or missing tissue comprising:
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providing a tissue graft comprising one or more biocompatible protein materials, combined with one or more biocompatible solvents and one or more pharmacologically active agents, cells or combinations thereof, wherein the protein material(s), biocompatible solvent(s) and pharmacologically active agent(s), cells or combinations thereof are formed into a cohesive body having a solvent content of about 20% to 80% prior to compression and the cohesive body is compressed at a pressure of about 100 psi to 100,000 psi to remove bulk biocompatible solvent and generate additional intermolecular and intramolecular forces between one or more of the protein material(s), solvent(s) and/or active agent(s) to form the tissue graft having a solvent content of about 10% to 60%; and administering the tissue graft to a part of a patient'"'"'s body that is damaged, diseased or missing. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of making a tissue graft, comprising the steps of:
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(a) preparing a coatable composition comprising one or more biocompatible protein materials and one or more biocompatible solvents; (b) forming the coatable composition into a cohesive body having a solvent content of about 20% to 80% prior to compression; and (c) compressing the cohesive body at a pressure of about 100 psi to 100,000 psi to remove bulk biocompatible solvent to form a tissue graft having a solvent content of about 10% to 60%. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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Specification