MARKERS TO PREDICT AND MONITOR RESPONSE TO AURORA KINASE B INHIBITOR THERAPY
First Claim
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1. A method of classifying a patient for eligibility for treatment with an Aurora kinase B inhibitor, the method comprising the steps of:
- a) receiving a test sample from a patient;
b) determining the presence or absence of a copy number gain for the (1) ABCB1 gene at chromosome locus 7q21.1;
or (2) ABCB4 gene at chromosome locus 7q21.1, wherein the determining is performed by in situ hybridization, polymerase chain reaction, or nucleic acid microarray assay; and
c) classifying the patient as being eligible for receiving treatment with an Aurora kinase B inhibitor based on the presence or absence of a copy number gain for the (1) ABCB1 gene at chromosome locus 7q21.1;
or (2) ABCB4 gene at chromosome locus 7q21.1.
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Abstract
The present invention relates to identifying the presence or absence of one or more copy number gains in the ABCB1 gene, the ABCB4 gene or combinations thereof, identifying patients eligible to receive Aurora kinase inhibitor therapy, either as monotherapy or as part of combination therapy, and monitoring patients'"'"' response to such therapy.
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Citations
24 Claims
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1. A method of classifying a patient for eligibility for treatment with an Aurora kinase B inhibitor, the method comprising the steps of:
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a) receiving a test sample from a patient; b) determining the presence or absence of a copy number gain for the (1) ABCB1 gene at chromosome locus 7q21.1;
or (2) ABCB4 gene at chromosome locus 7q21.1, wherein the determining is performed by in situ hybridization, polymerase chain reaction, or nucleic acid microarray assay; andc) classifying the patient as being eligible for receiving treatment with an Aurora kinase B inhibitor based on the presence or absence of a copy number gain for the (1) ABCB1 gene at chromosome locus 7q21.1;
or (2) ABCB4 gene at chromosome locus 7q21.1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of classifying a patient having a cancer that is resistant to treatment with an Aurora kinase B inhibitor, the method comprising the steps of:
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a) receiving a test sample from a patient; b) determining the presence or absence of a copy number gain for the (1) ABCB1 gene at chromosome locus 7q21.1;
or (2) ABCB4 gene at chromosome locus 7q21.1, wherein the determining is performed by in situ hybridization, polymerase chain reaction, or nucleic acid microarray assay;c) comparing the presence or absence of the copy number gain for the ABCB1 gene or the ABCB4 gene in the test sample against a baseline level or a predetermined level; and d) classifying the patient as having a cancer that is resistant to Aurora kinase B inhibitor treatment on (i) the presence of a copy number gain in the ABCB1 gene or the ABCB4 gene at chromosome locus 7q21.1; and
(ii) if the copy number gain in the test sample is higher then the baseline level or the predetermined level. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A kit comprising:
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(a) reagents for determining the presence or absence of a copy number gain for the ABCB1 gene; (b) instructions for performing the test. - View Dependent Claims (22)
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23. A kit comprising:
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(a) reagents for determining the presence or absence of a copy number gain for the ABCB4 gene; (b) instructions for performing the test. - View Dependent Claims (24)
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Specification