Methods for Screening Cells and Antibodies
First Claim
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1. A method of detecting a change in a cell growth pattern comprising:
- a) applying one or more cells to a location on a surface of a colorimetric resonant reflectance optical biosensor;
b) detecting a colorimetric resonant reflectance optical peak wavelength value (PWV) for the location;
c) incubating the one or more cells for a period of time or applying a test reagent or stimulus to the one or more cells;
d) detecting the colorimetric resonant reflectance optical PWV for the location; and
e) comparing the PWV of step b) to the PWV of step d);
wherein a difference between the colorimetric resonant reflectance optical PWV of step b) in relation to the colorimetric resonant reflectance optical PWV of step d) indicates a change in the cell growth pattern in the one or more cells.
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Abstract
The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
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Citations
12 Claims
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1. A method of detecting a change in a cell growth pattern comprising:
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a) applying one or more cells to a location on a surface of a colorimetric resonant reflectance optical biosensor; b) detecting a colorimetric resonant reflectance optical peak wavelength value (PWV) for the location; c) incubating the one or more cells for a period of time or applying a test reagent or stimulus to the one or more cells; d) detecting the colorimetric resonant reflectance optical PWV for the location; and e) comparing the PWV of step b) to the PWV of step d); wherein a difference between the colorimetric resonant reflectance optical PWV of step b) in relation to the colorimetric resonant reflectance optical PWV of step d) indicates a change in the cell growth pattern in the one or more cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification