METHOD FOR STERILIZATION OF BIOLOGICAL PREPARATIONS
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Abstract
Provided is a method for the sterilization of a biological preparation including desired viable biological entities. The method includes irradiating a dried (e.g. freeze-dried) biological preparation with UV radiation at an intensity and for a duration sufficient to reduce the amount or activity of living-matter contaminants in the biological preparation, the intensity and duration selected such that at least part of the desired biological entities in the sample remains viable. The described method is particularly suitable for the reduction of the amount or activity of contaminants such as bacteria or viruses from biological preparations including red blood cells or platelets.
58 Citations
15 Claims
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1. -6. (canceled)
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7. A method for sterilizing a biological preparation comprising a viable eukaryotic nucleus free cell, the method comprising:
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irradiating a freeze-dried biological preparation comprising a viable eukaryotic nucleus free cell with UV radiation at an intensity and for a duration sufficient to reduce the amount or activity of living-matter contaminants in the freeze-dried biological preparation, the intensity and duration selected such that at least part of the viable biological entity in the freeze-dried biological preparation remains viable, wherein the freeze-dried biological preparation does not comprise a sensitizing agent and the method does not comprise adding a sensitizing agent. - View Dependent Claims (8, 12, 13, 14)
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9. -11. (canceled)
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15. -16. (canceled)
Specification