Patient Monitoring Using Combination of Continuous Wave Spectrophotometry and Phase Modulation Spectrophotometry
First Claim
1. A method for non-invasive spectrophotometric monitoring of oxygen saturation levels in a tissue volume of a patient during a patient monitoring session, said patient monitoring session including a reference interval and a monitoring interval subsequent to said reference interval, comprising:
- receiving, in association with said reference interval, first information acquired from phase modulation spectrophotometry-based (PMS-based) monitoring of the tissue volume, said first information being representative of at least one absolute oxygen saturation level in a respective at least one relatively shallow region of the tissue volume;
receiving, in association with said reference interval, second information acquired from continuous wave spectrophotometry-based (CWS-based) monitoring of the tissue volume, said second information being representative of at least one non-absolute oxygen saturation level in a respective at least one relatively deep region of the tissue volume;
determining, based on said first and second information associated with the reference interval, a mapping between said second information and at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region of the tissue volume;
receiving, on a continuing basis during the monitoring interval, the second information acquired from the CWS-based monitoring of the tissue volume;
computing, on a continuing basis during the monitoring interval, the at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region by applying said determined mapping to said second information received during the monitoring interval;
displaying, on a continuing basis during the monitoring interval, said at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region on an output display.
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Accused Products
Abstract
Non-invasive spectrophotometric monitoring of oxygen saturation levels based on a combination of continuous wave spectrophotometry (CWS) and phase modulation spectrophotometry (PMS) is described. First information representative of absolute oxygen saturation levels in relatively shallow regions of a patient tissue volume are acquired from PMS-based monitoring thereof during a reference interval. Second information representative of non-absolute oxygen saturation levels in relatively deep regions of the tissue volume are acquired from CWS-based monitoring thereof during the reference interval. Based on the first and second information acquired during the reference interval, a mapping is automatically determined between the second information and estimated absolute oxygen saturation metrics for the relatively deep regions. On a continuing basis during a monitoring interval subsequent to the reference interval, the second information continuously acquired from CWS-based monitoring of the tissue volume are continuously mapped into estimated absolute oxygen saturation metrics, which are continuously displayed on a display output.
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Citations
20 Claims
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1. A method for non-invasive spectrophotometric monitoring of oxygen saturation levels in a tissue volume of a patient during a patient monitoring session, said patient monitoring session including a reference interval and a monitoring interval subsequent to said reference interval, comprising:
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receiving, in association with said reference interval, first information acquired from phase modulation spectrophotometry-based (PMS-based) monitoring of the tissue volume, said first information being representative of at least one absolute oxygen saturation level in a respective at least one relatively shallow region of the tissue volume; receiving, in association with said reference interval, second information acquired from continuous wave spectrophotometry-based (CWS-based) monitoring of the tissue volume, said second information being representative of at least one non-absolute oxygen saturation level in a respective at least one relatively deep region of the tissue volume; determining, based on said first and second information associated with the reference interval, a mapping between said second information and at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region of the tissue volume; receiving, on a continuing basis during the monitoring interval, the second information acquired from the CWS-based monitoring of the tissue volume; computing, on a continuing basis during the monitoring interval, the at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region by applying said determined mapping to said second information received during the monitoring interval; displaying, on a continuing basis during the monitoring interval, said at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region on an output display. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for non-invasive spectrophotometric monitoring of oxygen saturation levels in a tissue volume of a patient during a patient monitoring session, the patient monitoring session including a reference interval and a monitoring interval subsequent to the reference interval, comprising:
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a phase modulation spectrophotometry (PMS) subsystem for PMS-based monitoring of the tissue volume, the PMS subsystem generating first information representative of at least one absolute oxygen saturation level in a respective at least one relatively shallow region of the tissue volume; a continuous wave spectrophotometry (CWS) subsystem for CWS-based monitoring of the tissue volume, the CWS subsystem generating second information representative of at least one non-absolute oxygen saturation level in a respective at least one relatively deep region of the tissue volume; a computer coupled with said PMS subsystem and said CWS subsystem and being programmed to;
(a) determine, based on said first information and said second information as acquired during said reference interval, a mapping between said second information and at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region of the tissue volume; and
(b) compute, on a continuing basis during the monitoring interval, the at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region by applying said determined mapping to said second information as acquired during the monitoring interval; andan output display for displaying, on a continuing basis during the monitoring interval, the at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region of the tissue volume. - View Dependent Claims (14, 15, 16, 17)
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18. A computer readable medium tangibly embodying one or more sequences of instructions wherein execution of the one or more sequences of instructions by one or more processors causes the one or more processors to facilitate non-invasive spectrophotometric monitoring of oxygen saturation levels in a tissue volume of a patient during a patient monitoring session, said patient monitoring session including a reference interval and a monitoring interval subsequent to said reference interval, including performing the steps of:
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receiving, in association with said reference interval, first information acquired from phase modulation spectrophotometry-based (PMS-based) monitoring of the tissue volume, said first information being representative of at least one absolute oxygen saturation level in a respective at least one relatively shallow region of the tissue volume; receiving, in association with said reference interval, second information acquired from continuous wave spectrophotometry-based (CWS-based) monitoring of the tissue volume, said second information being representative of at least one non-absolute oxygen saturation level in a respective at least one relatively deep region of the tissue volume; determining, based on said first and second information associated with the reference interval, a mapping between said second information and at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region of the tissue volume; receiving, on a continuing basis during the monitoring interval, the second information acquired from the CWS-based monitoring of the tissue volume; computing, on a continuing basis during the monitoring interval, the at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region by applying said determined mapping to said second information received during the monitoring interval; causing to be displayed, on a continuing basis during the monitoring interval, said at least one estimated absolute oxygen saturation metric applicable to the respective at least one relatively deep region on an output display. - View Dependent Claims (19, 20)
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Specification