DEVICE,GAS MIXTURE AND METHOD FOR LUNG DIAGNOSIS

• US 20100198095A1
• Filed: 09/05/2008
• Published: 08/05/2010
• Est. Priority Date: 09/07/2007
• Status: Abandoned Application

• Current Assignee: Eco Medics AG (Eco Physics AG)
• Original Assignee: Eco Medics AG (Eco Physics AG)
• Inventors: Isler, Rudolf
• Application Number:
  US12/733,529
• Publication Number:
  US 20100198095A1
• Time in Patent Office: Days
• US Class Current: 600/532
• CPC Class Codes: A61B 5/0813 Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
• CPC Class Codes: A61K 49/00 Preparations for testing in vivo

Abstract

The invention relates to a lung diagnostic device, namely one for determining the ventilation homogeneity (VH) of a spontaneously breathing or artificially respirated patient as well as a gas mix for use in such a device. In this respect the difference in the composition of the exhaled test gas from the composition of the inhaled test gas serves for the evaluation of the ventilation homogeneity.

Claims

1. A device (10) for determining the ventilation homogeneity (VH) of a spontaneously breathing or artificially respirated patient (P), characterized in that it comprises:

at least one source (11) for a breathable test gas mix having essentially the same molecular mass sum (MMS) as ambient air (AA) or as a reference gas mix from a second source (112), but which differs from the ambient air (AA) or the reference gas mix from the second source (112) by addition of at least one specifically lighter inert gas (I1) and at least one specifically heavier inert gas (I2), and

at least one unit (12) for determining the molecular mass sums (MMS) of the gas mixtures exhaled by the patient.

2. The device (10) according to claim 1, characterized in that the molecular mass sum of the test gas mix differs by less than 10%, preferably by less than 5%, more preferably by less than 2%, most preferably by less than 1% from the molecular mass sum of the ambient air (AA) or the reference gas mix from a second source (112).

3. The device (10) according to claim 1, characterized in that the reference gas mix from the second source (112) comprises oxygen in a concentration of 21 to 100, preferably 30 to 100, more preferably 50 to 100, most preferably 100 vol.-%.

4. The device (10) according to claim 1, characterized in that the test gas mix has a molecular mass sum of 28 to 33 g/mol, preferably about 29 or 32, more preferably 28.85 or 32.0 g/mol.

5. The device (10) according to claim 1, characterized in that the at least one specifically heavier inert gas (I2) in the test gas mix is selected from the group consisting of argon, neon, krypton, radon, xenon and SF₆ as well as mixtures thereof, preferably radon and SF₆ and more preferably SF₆.

6. The device (10) according to claim 1, characterized in that the at least one specifically lighter inert gas in the test gas mix is helium.

7. The device (10) according to claim 1, characterized in that the unit (12) for determining the molecular mass sum (MS) of the test gas mix exhaled by the patient (P) has a device for measuring the ultrasound speed in gases or gas mixtures and a unit (121) for calculating the molecular mass sum from the measured ultrasound speeds as well as a unit (122) for displaying the measured values.

8. The device (10) according to claim 1, characterized in that it comprises (c) a second source (112) for the reference gas mix, which essentially has the same molecular mass sum as ambient air but a higher oxygen content than ambient air and contains no supplement of the specifically heavier gas.

9. The device (10) according to claim 1, characterized in that the device (12) for determining the molecular mass sum comprises a unit (123) for calculating the measured values for standard conditions.

10. The device (10) according to claim 1, characterized in that it comprises units (14;

140;

141;

142) for switching from the gas mix of ambient air (AA) inhaled by the patient (P) to the test gas mix delivered from source (11) and back;

or for switching from the test gas mix from source (112) inhaled by the patient (P) to the test gas mix from source (11) and back.

16. A method of using of a test gas mix according to claim 11 comprising using the test gas mix in the device of claim 1.

11. A test gas mix for determining the ventilation homogeneity (VH) of a spontaneously breathing or artificially respirated patient, characterized in that the test gas mix is a breathable gas mix, which has essentially the same molecular mass sum (MMS) as ambient air (AA) or a reference gas mix, but differs from these by at least one added specifically heavier gas (I2).

12. The test gas mix according to claim 11, characterized in that the molecular mass sum of the test gas mix differs by less than 10%, preferably by less than 5%, more preferably by less than 2%, most preferably by less than 1% from the molecular mass sum of the ambient air (AA) or the reference gas mix.

13. The test gas mix according to claim 11, characterized in that the test gas mix has a molecular mass sum of 28 to 33 g/mol, preferably about 29 or 32, more preferably 28.85 or 32.0 g/mol.

14. The test gas mix according to claim 11, characterized in that the at least one specifically heavier inert gas (I2) in the test gas mix is selected from the group consisting of argon, neon, krypton, radon, xenon and SF₆ as well as mixtures thereof, preferably radon and SF₆ and more preferably SF₆.

15. The test gas mix according to claim 11, characterized in that the at least one specifically lighter inert gas is helium.

17. A method for determining the ventilation homogeneity (VH) of a spontaneously breathing or artificially respirated patient (P), characterized in that the patient:

inhales actively or passively and in a controlled manner a breathable test gas mix, which essentially has the same molecular weight sum (MMS) as ambient air or a reference gas mix, but differs from both by addition of at least one specifically heavier inert gas (I2) and a sufficient proportion of a specifically lighter gas (I1), in order to adjust the molecular mass sum of the test gas to the about same value of the molecular mass sum of ambient air or the reference gas, and that the molecular mass sum (MMS) of the test gas exhaled by the patient is determined in order to evaluate the ventilation homogeneity of the patient from the differences in the test gas mix inhaled and exhaled by the patient.

18. The method according to claim 17, characterized in that in a test phase preceding the active breathing or passive respiration with the test gas mix the patient actively or passively inhales and exhales normal air or reference gas mix in a controlled manner in order to normalize conditions of the test gas breathing.

19. The method according to claim 17, characterized in that the at least one specifically heavier inert gas (I2) in the test gas mix is selected from the group consisting of argon, neon, krypton, radon, xenon and SF₆ as well as mixtures thereof, preferably radon and SF₆ and more preferably SF₆.

20. The method according to claim 17, characterized in that the at least one specifically lighter inert gas is helium.

21. The method according to claim 17, characterized in that the molecular mass sum of the test gas mix differs by less than 10%, preferably by less than 5%, more preferably by less than 2%, most preferably by less than 1% from the molecular mass sum of the ambient air (AA) or the reference gas.

22. The method according to claim 17, characterized in that the gas mix used as reference gas comprises oxygen in a concentration of 21 to 100, preferably 30 to 100, more preferably 50 to 100, most preferably 100 vol.-%.

23. The method according to claim 17, characterized in that the test gas mix has a molecular mass sum of 28 to 33 g/mol, preferably about 29 to 32, more preferably 28.85 or 32.0 g/mol.

24. The method according to claim 17, characterized in that for determining the molecular mass sum (MMS) of the test gas mix exhaled by the patient (P) a measurement of the ultrasound speed in gases or gas mixtures is used and the measured ultrasound speeds are calculated into molecular mass sums.