SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION OUTLET STREAMS
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Abstract
A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid'"'"'s properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
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Citations
85 Claims
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1-65. -65. (canceled)
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66. A device for exchanging components between a first fluid and a second fluid, the device comprising:
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a channel having; first and second fluid inlets; and first and second fluid outlets at portions of the channel downstream from the corresponding first and second fluid inlets, the first fluid outlet having a filter therein that forms a portion of a wall of the channel, wherein the channel is configured such that the first and second fluids enter the channel through the respective first and second fluid inlets and exit the channel through the respective first and second fluid outlets and such that the first and second fluids form adjacent layers in the channel with components diffusing between the first and second fluid layers. - View Dependent Claims (67, 68, 69, 70, 71, 72, 73, 74, 75, 76)
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77. A device for component exchange between fluids, comprising:
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an exchange channel configured such that, along at least a portion of a length thereof, a first fluid layer adjacent to and in contact with a pair of second fluid layers is formed between the pair of second fluid layers, wherein the exchange channel has an outlet for each second fluid layer in a respective wall of the channel, and each outlet has a filter therein forming a portion of said channel wall so as to prevent a component of the first fluid from exiting the channel with the second fluid layer through said outlet. - View Dependent Claims (78, 79, 80, 81, 82, 83)
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84. A device for component exchange between fluids, the device comprising:
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a microfluidic channel having one or more wall filters; and a pair of extraction fluid layers flowing in the channel, each extraction fluid layer flowing adjacent to a wall of the channel such that a first fluid layer flowing between said pair is isolated from said walls of the channel, wherein components in the first fluid layer diffuse into the extraction fluid layers, and the wall filters retain within the channel first components in the extraction fluid exiting the channel through said wall filters. - View Dependent Claims (85)
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Specification