CLOSED-LOOP NEUROSTIMULATION TO TREAT PULMONARY EDEMA
First Claim
1. A method comprising:
- sensing a physiological parameter indicative of lung wetness within a patient;
generating a neurostimulation signal configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient to mitigate lung wetness based on the sensed physiological parameter; and
delivering the neurostimulation signal to the patient.
1 Assignment
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Accused Products
Abstract
Neurostimulation to mitigate lung wetness is delivered to a patient based on a sensed parameter indicative of lung wetness. The neurostimulation is configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient. In some examples, a patient response to the neurostimulation therapy may be detected to modify the neurostimulation therapy. The patient response may include, for example, changes in the contractility of a heart of the patient, changes in the heart rate, heart rate variability or blood pressure of the patient, changes in a bladder size of the patient, changes in bladder functional activity of the patient, changes in urine flow, changes in lung function, changes in lung composition, or changes in the nerve activity of the patient.
57 Citations
32 Claims
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1. A method comprising:
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sensing a physiological parameter indicative of lung wetness within a patient; generating a neurostimulation signal configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient to mitigate lung wetness based on the sensed physiological parameter; and delivering the neurostimulation signal to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A system comprising:
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a sensor that senses a physiological parameter indicative of lung wetness within a patient; a stimulation generator; and a processor that controls the stimulation generator to generate and deliver a neurostimulation signal to the patient based on the sensed physiological parameter, wherein the neurostimulation signal is configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient to mitigate lung wetness. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A system comprising:
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means for sensing a physiological parameter indicative of lung wetness within a patient; means for generating a neurostimulation signal configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient to mitigate lung wetness based on the sensed physiological parameter; and means for delivering the neurostimulation signal to the patient. - View Dependent Claims (28, 29, 30)
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31. A computer-readable medium comprising instructions that cause a processor to control a stimulation generator to generate and deliver a neurostimulation signal to a patient based on a sensed physiological parameter indicative of lung wetness, wherein the neurostimulation signal is configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient to mitigate lung wetness.
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32. A method of mitigating lung wetness of a lung of a patient, wherein the method is characterized by implanting a medical device in the patient, the medical device comprising:
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a sensor that senses a physiological parameter indicative of lung wetness within a patient; a stimulation generator; and a processor that controls the stimulation generator to generate and deliver a neurostimulation signal to the patient based on the sensed physiological parameter, wherein the neurostimulation signal is configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient to mitigate lung wetness.
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Specification