BREATH ACTUATED NASAL PUMP
First Claim
1. A nasal drug delivery device comprising:
- a housing including a spray port;
a reservoir housing a liquidous medicament;
a selectively actuable pump supported by said housing and operatively connecting said reservoir to said spray port;
said pump having a plunger controlling operation thereof;
a deformable drive element operatively connected to said plunger and elastically deformable between a higher potential energy state and lower potential energy state;
a breath actuated triggering mechanism associated with said housing and including a mouthpiece and a diaphragm, said triggering mechanism controlling release of said drive element from said higher potential energy state to said lower potential energy state wherein a pressure differential across said diaphragm, higher towards said mouthpiece, causes said drive element to change from said higher state to said lower state, said plunger moving in response thereto to thereby cause said pump to supply said medicament to said spray port.
1 Assignment
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Accused Products
Abstract
A breath actuated nasal drug delivery device includes a housing having a spray port; a reservoir housing a liquidous medicament; and a selectively actuable pump. A breath actuated triggering mechanism includes a mouthpiece and a diaphragm. A pressure differential across the diaphragm causes an elastically deformable drive element (e.g., spring) to release stored potential energy, causing the pump'"'"'s plunger to move to thereby pump the medicament to the spray port. A cocking lever can be pivotally mounted to the housing for causing the drive element to store potential energy. The triggering mechanism can include a cam element pivotally attached to the housing and the diaphragm that rotates in response to movement of the diaphragm. A follower element can be pivotally connected to the plunger for movement therewith; the follower element releasably engages the cam element. Related methods are also described.
47 Citations
44 Claims
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1. A nasal drug delivery device comprising:
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a housing including a spray port; a reservoir housing a liquidous medicament; a selectively actuable pump supported by said housing and operatively connecting said reservoir to said spray port;
said pump having a plunger controlling operation thereof;a deformable drive element operatively connected to said plunger and elastically deformable between a higher potential energy state and lower potential energy state; a breath actuated triggering mechanism associated with said housing and including a mouthpiece and a diaphragm, said triggering mechanism controlling release of said drive element from said higher potential energy state to said lower potential energy state wherein a pressure differential across said diaphragm, higher towards said mouthpiece, causes said drive element to change from said higher state to said lower state, said plunger moving in response thereto to thereby cause said pump to supply said medicament to said spray port. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A nasal drug delivery device comprising:
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a housing having a spray port; a reservoir housing a liquidous medicament; a selectively actuable pump supported by said housing and operatively connecting said reservoir to said spray port;
said pump having a plunger controlling operation thereof;an elastically deformable drive element operatively connected to said plunger; a breath actuated triggering mechanism associated with said housing and comprising a mouthpiece and a diaphragm; said device moveable between a cocked configuration and a delivery configuration; wherein said drive element is held in a first relatively higher potential energy state and said plunger is relatively undepressed in said cocked configuration;
wherein said drive element is in a relatively lower potential energy state and said plunger is relatively depressed in said delivery configuration wherein blowing into said mouthpiece causes said diaphragm to move so as to release said drive element from said first state and thereby depress said plunger. - View Dependent Claims (17, 18, 19, 20)
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21. A nasal drug delivery device comprising:
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a housing having a spray port; a reservoir housing a liquidous medicament; a selectively actuable pump supported by said housing and operatively connecting said reservoir to said spray port;
said pump having a plunger controlling operation thereof;a cocking lever pivotally mounted to said housing for movement between a first position and a second position; a first elastic element disposed operatively between said plunger and said cocking lever, wherein movement of said cocking lever to said second position causes said elastic element to store energy; and a triggering mechanism comprising a diaphragm and a selectively breakable linkage connecting said diaphragm to said plunger, wherein inward movement of said diaphragm causes said linkage to break, thereby causing said plunger to be depressed by the release of said energy stored in said elastic element. - View Dependent Claims (22, 23, 24, 25)
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26. A method of administering a medicament nasally to a user comprising the steps of:
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providing a nasal delivery device, the nasal delivery device comprising; a housing having a spray port; a reservoir housing a liquidous medicament; a selectively actuable pump supported by the housing and operatively connecting the reservoir to the spray port;
the pump having a plunger controlling operation thereof;a cocking lever pivotally mounted to the housing for movement between a first position and a second position; a first elastic element disposed operatively between the plunger and the cocking lever, storing energy in the first elastic element by moving the cocking lever to the second position while resisting movement of the plunger; and blowing into a mouthpiece associated with the housing; and
, in response thereto, releasing the stored energy to depress the plunger to thereby cause delivery of a portion of the medicament into the nasal passages of a user. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method of administering a medicament nasally to a user comprising the steps of:
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providing a nasal delivery device comprising; a housing comprising a distal end portion and a proximal end portion and comprising a spray port disposed proximate the proximal end portion;
the spray port configured to be inserted in a human user'"'"'s nose;
a reservoir housing a liquid medicament;
a manually powered pump supported by the housing and operatively connecting the reservoir to the spray port;
a deformable drive element operatively connected to the plunger and elastically deformable between a higher potential energy state and lower potential energy state;
a breath actuated triggering mechanism associated with the housing and comprising a mouthpiece and a diaphragm;
the triggering mechanism controlling release of the drive element from the higher potential energy state to the lower potential energy state;disposing the proximal end portion proximate the user'"'"'s face and the distal end portion distal from the user'"'"'s face;
a forward direction defined as extending from the distal end portion toward the proximal end portion;blowing into the mouthpiece in a direction generally opposite the forward direction so as to deform the diaphragm inwardly; in response to the diaphragm deformation, releasing the drive element to change from the higher potential state to the lower potential state to supply a force to depress a plunger of the pump; in response to the plunger depression, delivering a portion of the medicament into the nasal passages of the user by generating a spray of medicament from the spray port in a spray direction. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44)
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Specification