EMBEDDED BODILY FLUID ANALYSIS DEVICE

• US 20100200400A1
• Filed: 01/25/2010
• Published: 08/12/2010
• Est. Priority Date: 02/06/2009
• Status: Abandoned Application

• Current Assignee: Commissariat a L'Energie Atomique (French Alternative Energies and Atomic Energy Commission)
• Original Assignee: Commissariat a L'Energie Atomique (French Alternative Energies and Atomic Energy Commission)
• Inventors: REVOL-CAVALIER, Frédéric
• Application Number:
  US12/693,038
• Publication Number:
  US 20100200400A1
• Time in Patent Office: Days
• US Class Current: 204/416
• CPC Class Codes: A61B 10/0051 for taking saliva or sputum samples devices for receiving spittle A61J9/00
• CPC Class Codes: A61B 2010/0009 Testing for drug or alcohol abuse
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/20 for measuring urological functions restricted to the evaluation of the urinary system A61B5/4375 takes precedence
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/4266 sweat secretion
• CPC Class Codes: A61B 5/4277 saliva secretion
• CPC Class Codes: A61B 5/4283 gastrointestinal secretions, e.g. bile production
• CPC Class Codes: A61B 5/4881 Determining interstitial fluid distribution or content within body tissue measuring analytes in interstitial fluid in-vivo A61B5/1451
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0838 Capillaries
• CPC Class Codes: B01L 2300/0877 Flow chambers
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: G01N 27/07 Construction of measuring vessels; Electrodes therefor
• CPC Class Codes: G01N 33/5438 Electrodes

Abstract

The invention relates to an embedded bodily fluid analysis device comprising a measuring cell containing the bodily fluid to be analyzed, at least one reference cell containing a reference standard and an electronic measuring circuit. The measuring cell is provided with at least one work electrode of the measuring cell and with at least one reference electrode of the measuring cell. The reference cell is provided with at least one work electrode of the reference cell formed by the same material or materials as a work electrode of the measuring cell and with at least one reference electrode of the reference cell formed by the same material or materials as a reference electrode of the measuring cell.

Claims

1. A bodily fluid analysis device comprising:

a measuring cell containing the bodily fluid to be analyzed and provided with at least one work electrode of the measuring cell and at least one reference electrode of the measuring cell,

at least one reference cell containing a reference standard and provided with at least one work electrode of the reference cell and at least one reference electrode of the reference cell and,

an electronic measuring circuit connected to the work and reference electrodes of the measuring cell and of the reference cell,

a device wherein the measuring cell has an inlet orifice and an outlet orifice of the bodily fluid, each orifice being connected to microfluidic draining means, and the reference cell has two sealed-off orifices, and at least one work electrode of the reference cell formed by the same material or materials as a work electrode of the measuring cell, and at least one reference electrode of the reference cell formed by the same material or materials as a reference electrode of the measuring cell.

2. The device according to claim 1 comprising a support.

3. The device according to claim 1 wherein the work electrode of the reference cell and the reference electrode of the reference cell are respectively identical to the work electrode of the measuring cell and to the reference electrode of the measuring cell in size, shape, number and position.

4. The device according to claim 1 wherein the reference cell has identical dimensions to those of the measuring cell.

5. The device according to claim 1 wherein the measuring cell and the reference cell have a capillary structure.

6. The device according to claim 5 wherein the measuring cell and the reference cell are capillary tubes made from a material chosen from glass, molten silica and a polymer material.

7. The device according to claim 1 wherein the microfluidic draining means are formed by collecting means of the bodily fluid connected to the inlet orifice of the measuring cell and a microfluidic pump connected to the outlet orifice of the measuring cell.

8. The device according to claim 1 wherein the analysis device is in contact with a person'"'"'s skin to analyze sweat, and the collecting means consist of a network of channels integrated in the support.

9. The device according to claim 1 wherein the analysis device is in contact with a person'"'"'s skin to analyze sweat, and the collecting means consist of a collect pocket of the bodily fluid fixed to the support.

10. The device according to claim 1 wherein the microfluidic pump is formed by an absorbent fabric integral to the measuring cell and sealing off the outlet orifice.

11. The device according to claim 1 wherein at least one of the orifices of the reference cell is sealed off by a removable plug.

12. The device according to claim 1 wherein the support is formed by a flexible material.

13. The device according to claim 12 wherein the support is formed by a material chosen from a synthetic, natural or artificial textile, a polymer material and a semiconducting material.

14. The device according to claim 1 wherein the work and reference electrodes of the measuring cell and the work and reference electrodes of the reference cell are metallic electrodes.

15. The device according to claim 1 wherein at least one work electrode of the measuring cell and at least one work electrode of the reference cell is an ion selective electrode which reacts selectively to specific ions.

16. The device according to claim 1 wherein the reference standard is a liquid solution or a gel.

17. The device according to claim 1 wherein the reference standard is a solid standard.