METHOD AND APPARATUS FOR PERFORMING OPTICAL MEASUREMENTS OF A MATERIAL

• US 20100201968A1
• Filed: 09/10/2009
• Published: 08/12/2010
• Est. Priority Date: 10/07/2002
• Status: Abandoned Application

• Current Assignee: IntelliDx, Inc.
• Original Assignee: IntelliDx, Inc.
• Inventors: Nigar, Ron, Pesach, Benny, Bitton, Gabriel
• Application Number:
  US12/557,343
• Publication Number:
  US 20100201968A1
• Time in Patent Office: Days
• US Class Current: 356/39
• CPC Class Codes: G01N 2021/6491 Measuring fluorescence and transmission; Correcting inner filter effect
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: G01N 21/64 Fluorescence; Phosphorescence

Abstract

A method of determining an optical parameter or function thereof for a liquid, the method comprising: flowing the liquid through a flow cell; transmitting a pulse of light into the liquid in the flow cell; generating a signal responsive to energy that the material emits responsive to a portion of the light from the light pulse that is absorbed by the liquid; and using the signal to determine the optical parameter or function thereof.

Claims

1. An apparatus for determining an optical parameter or function thereof for blood ex vivo, the apparatus comprising:

(a) a first conduit through which blood flows from a patient'"'"'s vascular system into a flow cell ex vivo, the flow cell having a cross-section dimension greater than an absorption length in the blood for light which the optical parameter or function thereof is determined;

(b) a pump which circulates the patient'"'"'s blood through the flow cell;

(c) a light source that transmits a pulse of light in the blood in the flow cell along the cross section dimension;

(d) a detector that receives energy emitted by the material responsive to light from the light pulse that is absorbed by the material and generates a signal responsive to the received energy;

(e) a processor that receives that signal and uses it to determine the optical parameter or function thereof; and

(f) a second conduit through which blood from the ex vivo flow cell recirculates into the patient'"'"'s vascular system.