COMPOSITIONS AND METHODS FOR TREATING POST-OPERATIVE PAIN USING BUPIVACAINE AND AN ANTI-ONFLAMMATORY AGENT
First Claim
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1. An implantable drug depot useful for localized delivery to a site beneath the skin of a patient, the drug depot comprising:
- a therapeutically effective amount of bupivacaine and an anti-inflammatory agent, wherein the drug depot is capable of releasing the bupivacaine and the anti-inflammatory agent over three days to fourteen days where the depot is capable of releasing a first percentage of bupivacaine relative to a total amount of bupivacaine over the first two days and a first percentage of anti-inflammatory agent relative to a total amount of anti-inflammatory agent over the first two days, wherein the first percentage of anti-inflammatory agent is less than the first percentage of bupivacaine.
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Abstract
Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and an anti-inflammatory agent at or near a target site, one can alleviate or prevent pain while preventing undesirable levels of inflammation. This administration of bupivacaine and an anti-inflammatory agent is particularly useful following surgery.
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Citations
20 Claims
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1. An implantable drug depot useful for localized delivery to a site beneath the skin of a patient, the drug depot comprising:
- a therapeutically effective amount of bupivacaine and an anti-inflammatory agent, wherein the drug depot is capable of releasing the bupivacaine and the anti-inflammatory agent over three days to fourteen days where the depot is capable of releasing a first percentage of bupivacaine relative to a total amount of bupivacaine over the first two days and a first percentage of anti-inflammatory agent relative to a total amount of anti-inflammatory agent over the first two days, wherein the first percentage of anti-inflammatory agent is less than the first percentage of bupivacaine.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of treating or preventing postoperative pain or inflammation in a patient in need of such treatment, the method comprising co-administering a first biodegradable drug depot and a second biodegradable drug depot to a target site, wherein said first biodegradable drug depot releases an effective amount of bupivacaine over a period of 3 to 14 days and wherein said second biodegradable drug depot releases an anti-inflammatory agent over a period of 3 to 14 days.
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20. An implantable drug depot useful for localized delivery to a site beneath the skin of a patient, the drug depot comprising:
- a therapeutically effective amount of bupivacaine and an anti-inflammatory agent, wherein the drug depot is capable of releasing the bupivacaine and the anti-inflammatory agent over five days to twelve days and wherein the drug depot is capable of releasing a first percentage of bupivacaine relative to a total amount of bupivacaine over the first two days and a first percentage of anti-inflammatory agent relative to a total amount of anti-inflammatory agent over the first two days, wherein the first percentage of bupivacaine is greater than the first percentage of the anti-inflammatory agent and wherein the anti-inflammatory agent is a COX-2 inhibitor.
Specification