BUPROPION HYDROBROMIDE AND THERAPEUTIC APPLICATIONS
First Claim
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1. A composition comprising bupropion hydrobromide and at least one pharmaceutically acceptable excipient;
- wherein administration of an amount of a bupropion hydrobromide to a first rat results in less incidences of and/or less severe bupropion-induced seizures when compared to incidences of and/or severity of bupropion-induced seizures resulting from administration of an equivalent molar amount of bupropion hydrochloride to a second rat; and
wherein the incidences of and/or severity of bupropion-induced seizures are measured by an electroencephalogram analysis using a hippocampally implanted depth electrode.
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Abstract
Bupropion hydrobromide formulations as well as their use for the treatment of conditions is described.
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Citations
19 Claims
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1. A composition comprising bupropion hydrobromide and at least one pharmaceutically acceptable excipient;
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wherein administration of an amount of a bupropion hydrobromide to a first rat results in less incidences of and/or less severe bupropion-induced seizures when compared to incidences of and/or severity of bupropion-induced seizures resulting from administration of an equivalent molar amount of bupropion hydrochloride to a second rat; and wherein the incidences of and/or severity of bupropion-induced seizures are measured by an electroencephalogram analysis using a hippocampally implanted depth electrode. - View Dependent Claims (2, 3, 4, 5)
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6. A composition comprising bupropion hydrobromide and at least one pharmaceutically acceptable excipient;
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wherein administration of about 100 mg/kg of a bupropion hydrobromide to a first rat results in less incidences of and/or severity of bupropion-induced seizures when compared to incidences of and/or severity of bupropion-induced seizures resulting from administration of an equivalent molar amount of bupropion hydrochloride to a second rat; and wherein the incidences of and/or severity of bupropion-induced seizures are measured by an electroencephalogram analysis using a hippocampally implanted depth electrode.
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7. A method of treating a subject at risk of bupropion-induced seizures in need of bupropion treatment, the method comprising:
administering a composition comprising bupropion hydrobromide to said subject in an amount sufficient to treat said subject. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A method of reducing incidences of bupropion-induced seizures comprising:
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administering a pharmaceutically effective amount of bupropion hydrobromide to a subject in need of bupropion administration; wherein incidences of bupropion-induced seizures resulting from the administration of bupropion hydrobromide is less than incidences of bupropion-induced seizures resulting from administration of an equivalent molar amount of bupropion hydrochloride. - View Dependent Claims (14)
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15. A method of reducing incidences of bupropion-induced seizures comprising:
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administering a pharmaceutically effective amount of bupropion hydrobromide to a subject in need of bupropion administration; wherein administration of about 100 mg/kg of the bupropion hydrobromide to a first rat results in less incidences of bupropion-induced seizures when compared to incidences of bupropion-induced seizures resulting from administration of an equivalent molar amount of bupropion hydrochloride to a second rat; and wherein the incidences of bupropion-induced seizures in the first and second rats are measured by an electroencephalogram analysis using a hippocampally implanted depth electrode.
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- 16. A method of reducing the incidences of bupropion induced seizures comprising coadministration of a bromide salt with a bupropion salt, wherein the bromide salt is administered in an amount of less than about 3.5 mg/kg.
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19. A composition comprising bupropion hydrobromide and at least one pharmaceutically acceptable excipient;
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wherein administration of about 100 mg/kg of a bupropion hydrobromide used to manufacture the composition to a first rat results in less incidences of and/or severity of bupropion-induced seizures when compared to incidences of and/or severity of bupropion-induced seizures resulting from administration of an equivalent molar amount of bupropion hydrochloride to a second rat; and wherein the incidences of and/or severity of bupropion-induced seizures are measured by an electroencephalogram analysis using a hippocampally implanted depth electrode.
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Specification