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BUPROPION HYDROBROMIDE AND THERAPEUTIC APPLICATIONS

  • US 20100203128A1
  • Filed: 08/06/2008
  • Published: 08/12/2010
  • Est. Priority Date: 08/07/2007
  • Status: Abandoned Application
First Claim
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1. A composition comprising bupropion hydrobromide and at least one pharmaceutically acceptable excipient;

  • wherein administration of an amount of a bupropion hydrobromide to a first rat results in less incidences of and/or less severe bupropion-induced seizures when compared to incidences of and/or severity of bupropion-induced seizures resulting from administration of an equivalent molar amount of bupropion hydrochloride to a second rat; and

    wherein the incidences of and/or severity of bupropion-induced seizures are measured by an electroencephalogram analysis using a hippocampally implanted depth electrode.

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