METHODS OF TREATING HEPATIC ENCEPHALOPATHY
First Claim
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1. A method of treating or preventing hepatic encephalopathy (HE) comprising administering to a subject in need thereof a gastrointestinal (GI) specific antibiotic.
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Abstract
The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.
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Citations
96 Claims
- 1. A method of treating or preventing hepatic encephalopathy (HE) comprising administering to a subject in need thereof a gastrointestinal (GI) specific antibiotic.
- 3. A method of decreasing a subject'"'"'s risk of a hepatic encephalopathy (HE) breakthrough episode comprising administering a GI specific antibiotic to a subject suffering from HE.
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14. A method of maintaining remission of HE in a subject comprising administering a GI specific antibiotic to a subject suffering from HE.
- 15. A method of reducing the frequency of hospitalization visits by an HE patient, comprising administering a GI specific antibiotic to a subject suffering from HE.
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56. A method of treating or preventing HE comprising administering 550 mg of rifaximin for more than 28 days.
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57. A method of decreasing lactulose use in a subject, comprising:
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administering rifaximin to a subject daily that is being treated with lactulose; and tapering lactulose consumption. - View Dependent Claims (58, 59, 60, 61)
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62. A method of maintaining remission of HE in a subject comprising administering 550 mg of rifaximin BID.
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63. A method of increasing time to hospitalization for HE comprising, administering to a subject 550 mg of rifaximin two times per day (BID).
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64. A method of treating a patient suffering from hepatic encephalopathy, comprising:
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advising a patient suffering from hepatic encephalopathy that administration of rifaximin may induce cytochrome P450 activity; and administering rifaximin to the patient in order to treat the hepatic encephalopathy. - View Dependent Claims (65, 66, 67, 68, 69, 70)
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71. A method of administering rifaximin as a treatment for hepatic encephalopathy, comprising:
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advising a health care worker that patients being administered rifaximin as a treatment for hepatic encephalopathy may induce cytochrome P450 activity; and administering the rifaximin to the patient in order to treat the hepatic encephalopathy. - View Dependent Claims (72, 73, 74)
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- 75. A method of increasing the time between breakthrough events for a patient suffering from hepatic encephalopathy, comprising administering to the patient an effective amount of rifaximin that extends the time between hepatic encephalopathy breakthrough events.
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79. A method of lowering the risk of antibacterial resistance when treating chronically with an antibacterial composition, comprising administering rifaximin chronically to treat irritable bowel syndrome, travelers'"'"' diarrhea, small intestinal bacterial overgrowth, Crohn'"'"'s disease, pancreatitis, pancreatic insufficiency, peritonitis, hepatic encephalopathy, pouchitis, infectious diarrhea, inflammatory bowel disease, diverticular disease, Clostridium, C. difficile disease, H. pylori infection, enteritis and colitis and other related conditions. A method of alleviating caretaker burden comprising, administering rifaximin to a subject in need thereof to treat hepatic encephalopathy.
- 80. A method of reducing hospitalization rate comprising, administering rifaximin to a subject in need thereof to treat hepatic encephalopathy.
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85. A method of reducing the economic cost related to liver cirrhosis and/or associated HE comprising administering a subject suffering from HE a rifamycin class antibiotic.
- 86. A method of increasing the mental status in a subject comprising, administering rifaximin to the subject, thereby increasing the mental status in a subject.
- 89. The method of decreasing the number of overt HE episodes in a subject comprising, administering rifaximin to the subject, thereby decreasing the number of overt HE episodes.
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93. A method for increasing the chance of survival of a subject having HE, comprising administering to the subject rifaximin, thereby increasing the chance of survival for the subject.
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94. A method of administering rifaximin as a treatment for hepatic encephalopathy, comprising:
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advising a health care worker that rifaximin does not increase the risk of QT prolongation; and administering the rifaximin to the patient in order to treat the hepatic encephalopathy. - View Dependent Claims (2, 95, 96)
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94-1. A method of administering rifaximin as a treatment for hepatic encephalopathy, comprising:
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advising a health care worker that rifaximin does not significantly alter the Cmax, AUC0-t, or AUC0-∞
of midazolam; andadministering the rifaximin to the patient in order to treat the hepatic encephalopathy.
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95-2. The method of claim 94, wherein the subject is administered 1650 mg/day of rifazimin.
Specification