VALPROIC ACID DRUG DELIVERY SYSTEMS AND INTRAOCULAR THERAPEUTIC USES THEREOF
First Claim
Patent Images
1. An intraocular drug delivery system for treating a retinal condition, comprising:
- (a) a bioerodible polymer, and;
(b) a valproic acid associated with the bioerodible polymer.
1 Assignment
0 Petitions
Accused Products
Abstract
Biocompatible, bioerodible, sustained release drug delivery system formulated as implants, microspheres and high viscosity hyaluronic acid solutions comprise valproic acid as therapeutic agent and a biodegradable polymer, the system being effective, when placed intraocular (such as into the subtenon space or into the vitreous) to treat a retinal disease or condition.
41 Citations
20 Claims
-
1. An intraocular drug delivery system for treating a retinal condition, comprising:
-
(a) a bioerodible polymer, and; (b) a valproic acid associated with the bioerodible polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
- 11. An intraocular drug delivery implant for treating a retinal condition comprising 10 to 30 weight percent sodium valproate and 70 to 90 weight PLGA, the implant formed by homogenously mixing the valproate and the PLGA, the mixture then heated to a temperature between about 40 and about 180 C, followed by extrusion of the implant.
- 12. A method for treating a retinal condition, the method comprising the step of intraocular administration to a patient with a retinal condition of a drug delivery system comprising a bioerodible polymer, and a valproic acid associated with the bioerodible polymer.
-
17. A method for treating a macular edema, the method comprising the step of intravitreal administration to a patient with macula edema of a drug delivery system comprising a bioerodible polymer, and a valproic acid associated with the bioerodible polymer.
- 18. A method for reducing retinal tissue oxidative stress in a human patient, the method comprising the step of intravitreal administration to a human patient with oxidative stress retinal cells of a drug delivery system comprising a bioerodible polymer, and a valproic acid associated with the bioerodible polymer.
Specification