Microdialysis Catheter and a Method of Making a Microdialysis Catheter

• US 20100204565A1
• Filed: 10/17/2007
• Published: 08/12/2010
• Est. Priority Date: 10/18/2006
• Status: Active Grant

• Current Assignee: Maquet Critical Care AB (Getinge AB)
• Original Assignee: CMA Microdialysis AB
• Inventors: Falkén, Henrik, Liska, Jan
• Granted Patent: US 8,229,546 B2
• Time in Patent Office: Days
• US Class Current: 600/424
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61M 25/0009 Making of catheters or other medical or surgical tubes

Abstract

The invention relates to a microdialysis catheter comprising a multilumen tube (10) and a membrane (11), said tube exhibiting at least two longitudinally arranged inner channels (13,14), said channels extending from a proximal (20) end of the tube to the distal end (21) of the tube, whereat through-holes (12,15) are provided, one from each of said at least two channels to the outside of said tube, said channels (13,14) blocked for passage of liquid distally of the respective through-holes, a tubular membrane (11) arranged circumferentially around the tube (10) such as to cover the at least two through-holes (12,15), said membrane is sealingly fastened (22) to the tube thereby forming a dialysis chamber (18) between the tube and the membrane.

Claims

1-11. -11. (canceled)

12. A microdialysis catheter comprising a multilumen tube and a membrane, said tube exhibiting at least two longitudinally arranged inner flow channels, said at least two longitudinally arranged inner flow channels representing at least one in-flow channel and at least one outflow channel, said flow channels extending from a proximal end of the tube to a distal end of the tube, whereat through-holes are provided, one from each of said at least two flow channels to the outside of said tube, said flow channels blocked for passage of liquid distally of the respective through-holes, a tubular membrane arranged circumferentially around the tube such as to cover the at least two through-holes, wherein said membrane is sealingly fastened to the tube, thereby forming a dialysis chamber between the tube and the membrane, and wherein the flow channels are adapted to provide the same flow rate for the total in-flow, the total out-flow and the dialysis chamber flow, thus allowing a flow rate of 5-15 μ

l/minute.

13. A microdialysis catheter according to claim 12, comprising at least one further channel in the multilumen tube, said further channel extending between the proximal end of the tube to the distal end of the tube, said further channel adapted to house guide means and/or pressure measurement means and/or sampling/delivering means.

14. A microdialysis catheter according to claim 12, wherein the tube comprises extruded biocompatible polymeric material.

15. A microdialysis catheter according to claim 12, wherein the tubular membrane is arranged such as to have the selective layer on the outer circumference of the same.

16. A microdialysis catheter according to claim 12, wherein the membrane has a wall thickness of approximately 20-100 μ

m.

17. A microdialysis catheter according to claim 12, wherein the membrane has a wall thickness of approximately 30 to 80 μ

m.

18. A microdialysis catheter according to claim 12, wherein the inner diameter of the tubular membrane is approximately 1000-3000 μ

m.

19. A microdialysis catheter according to claim 12, wherein the inner diameter of the tubular membrane is approximately 1000-2000 μ

m.

20. A microdialysis catheter according to claim 12, comprising means for detection of the position of the catheter, said means responsive to ultra sound while using the same for microdialysis purposes.

21. A microdialysis catheter according to claim 12, comprising means for detection of the position of the catheter, said means operable to impart opaqueness to X-rays to the catheter such that it is detectable using X-rays while using the catheter for microdialysis purposes.

22. A microdialysis catheter according to claim 12, wherein the total in-flow rate, the total out-flow rate and the dialysis chamber flow rate have the same rate, and the rate is 5-15 μ

l/minute.

23. A method of making a microdialysis catheter according to claim 12, comprising

extruding a multilumen tube, said tube exhibiting at least two longitudinally arranged inner flow channels, said flow channels extending from a proximal end of the tube to the distal end of the tube,

providing in said at least two flow channels through-holes, one from each of said at least two flow channels to the outside of said tube,

blocking said flow channels for passage of liquid distally of the respective through-holes,

arranging a tubular membrane circumferentially around the tube such as to cover the at least two through-holes,

sealingly fastening said membrane to the tube thereby forming a dialysis chamber between the tube and the membrane.

24. A method according to claim 23 in which at least one further channel in the tube is provided during the extrusion.