IMPLANTABLE INTEGRATED CIRCUIT

• US 20100204766A1
• Filed: 12/22/2006
• Published: 08/12/2010
• Est. Priority Date: 12/22/2005
• Status: Abandoned Application

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Inventors: Arne, Lawrence, Bi, Yafei, Aria, Behrad, Leichner, Robert, Robertson, Timothy, Li, Haifeng, Zdeblick, Mark, Thompson, Todd, Jani, Nilay, Gelfandbein, Vladimier
• Application Number:
  US12/097,959
• Publication Number:
  US 20100204766A1
• Time in Patent Office: Days
• US Class Current: 607/119
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/362 Heart stimulators heart defibrillators A61N1/39
• CPC Class Codes: A61N 1/3686 configured for selecting the electrode configuration on a lead A61N1/3688 takes precedence
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37276 characterised by means for reducing power consumption during telemetry
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Embodiments of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Embodiments of the invention enable the required functionality for accurate long term control of effectors units, even ones present on multiplex carrier configurations, while provide for low power consumption. Aspects of the invention include implantable integrated circuits that have power extraction; energy storage; communication; and device configuration functional blocks, where these functional blocks are all present in a single integrated circuit on an intraluminal-sized support. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.

Claims

1. An implantable integrated circuit, said integrated circuit comprising:

a power extraction functional block;

an energy storage functional block;

a communication functional block; and

a device configuration functional block;

wherein said functional blocks are all present in a single integrated circuit on an intraluminal-sized support.

2. The integrated circuit according to claim 1, wherein substantially all of the functions of power extraction, energy storage, communication and device configuration employed by said circuit during use are provided by said single integrated circuit.

3. The integrated circuit according to claim 1, further comprising integrated corrosion protection films.

5. The integrated circuit according to claim 1, wherein a device configuration provided by said integrated circuit is functional without power being applied to said integrated circuit.

6. The integrated circuit according to claim 1, wherein a default configuration connecting one supply terminal to one or more effector electrodes is set in said integrated circuit upon power up of said circuit.

7. The integrated circuit according to claim 1, wherein said communication functional block employs an alternating current at a frequency above about 15 kHz.

8. The integrated circuit according to claim 1, wherein said device configuration functional block is configured to control one or more effectors.

9. The integrated circuit according to claim 8, wherein said integrated circuit further comprises a functional block that enables stimulation of tissue via said one or more effectors.

10. The integrated circuit according to claim 8, wherein said integrated circuit further comprises a functional block that enables low voltage transmission from tissue to said integrate circuit.

11. The integrated circuit according to claim 9, wherein said integrated circuit provides substantially charge-balanced transmission of a stimulation pulse.

12. The integrated circuit according to claim 8, wherein said device configuration block comprises a switching block between supply terminals and one or more effectors.

13. The integrated circuit according to claim 12, wherein said switching block comprises switching elements each comprised of two transistors between each effector and supply terminal.

14. The integrated circuit according to claim 13, wherein said two transistors share a common bulk that is electrically isolated from all other circuits.

15. The integrated circuit according to claim 14, wherein said two transistors comprise gates that are electrically connected.

16. The integrated circuit according to claim 15, wherein said two transistors comprise sources that are connected.

17. The integrated circuit according to claim 14, wherein said common bulk is electrically connected to a common source terminal.

18. The integrated circuit according to claim 15, wherein a control voltage applied to said gates is referenced to a voltage on said supply terminal.

19. The integrated circuit according to claim 1, further comprising a sleep functional block.

20. The integrated circuit according to claim 19, further comprising a wakeup functional block.

22. The integrated circuit according to claim 1, further comprising a current limiting functional block.

23. The integrated circuit according to claim 1, further comprising a voltage-clamping functional block.

24. The integrated circuit according to claim 1, further comprising a fault recovery functional block.

25. The integrated circuit according to claim 24, wherein said fault recovery functional block is configured to electrically isolate failed circuits or wires.

26. The integrated circuit according to claim 1, wherein said intraluminal-sized support has a largest surface area ranging from about 0.05 to about 5 mm².

27. The integrated circuit according to claim 1, wherein said integrated circuit is configured to have an average power consumption of about 100 μ

W or less.

28. The integrated circuit according to claim 1, wherein said integrated circuit is configured to have an average current draw while maintaining its configuration state of about 1 nA or less.

29. The integrated circuit according to claim 1, wherein said integrated circuit is configured to have an average current draw when the configuration state of the device is being changed that ranges from about 1 μ

A to about 100 μ

A.

31. The integrated circuit according to claim 1, wherein said integrated circuit is configured to operate a multi-effector satellite.

4. (canceled)

21. (canceled)

30. (canceled)

32-39. -39. (canceled)

40. An implantable effector unit comprising:

(a) an integrated circuit, said integrated circuit comprising;

(i) a power extraction functional block;

(ii) an energy storage functional block;

(iii) a communication functional block; and

(iv) a device configuration functional block;

wherein said functional blocks are all present in a single integrated circuit on an intraluminal-sized support; and

(b) at least one effector coupled to said integrated circuit.

41. The implantable effector unit according to claim 40, wherein said effector unit comprises two or more effectors coupled to said integrated circuit.

42. The implantable effector unit according to claim 41, wherein said two or more effectors are electrodes.

43. The implantable effector unit according to claim 42, wherein said two or more electrodes are segmented electrodes.

44-50. -50. (canceled)

51. An elongated flexible structure comprising a proximal end and a distal end, and at least one electrode assembly comprising:

(a) an integrated circuit, said integrated circuit comprising;

(i) a power extraction functional block;

(ii) an energy storage functional block;

(iii) a communication functional block; and

(iv) a device configuration functional block;

wherein said functional blocks are all present in a single integrated circuit on an intraluminal-sized support; and

(b) at least one two electrodes coupled to said integrated circuit.

52. The elongated flexible structure according to claim 51, wherein said structure is a vascular lead.

53. The elongated flexible structure according to claim 52, wherein said vascular lead comprises 2 or more electrode assemblies.

54. The elongated flexible structure according to claim 53, wherein said vascular lead is a multiplex vascular lead.

55. The elongated flexible structure according to claim 54, wherein said multiplex lead has 3 or less wires.

56. The elongated flexible structure according to claim 55, wherein said vascular lead includes only 2 wires.

57. The elongated flexible structure according to claim 55, wherein said vascular lead includes only 1 wire.

58. The elongated flexible structure according to claim 51, wherein said vascular lead includes an IS-1 connector at said proximal end.

59-69. -69. (canceled)

70. A kit comprising:

(a) a housing comprising a power source and an electrical stimulus control element; and

(b) a vascular lead comprising an elongated flexible structure comprising a proximal end and a distal end, and at least one electrode assembly comprising;

(i) an integrated circuit, said integrated circuit comprising a power extraction functional block, an energy storage functional block, a communication functional block, a device configuration functional block, wherein said functional blocks are all present in a single integrated circuit on an intraluminal-sized support; and

(ii) at least one two electrodes coupled to said integrated circuit.