Filter Assemblies

• US 20100204772A1
• Filed: 10/18/2007
• Published: 08/12/2010
• Est. Priority Date: 10/18/2006
• Status: Abandoned Application

• Current Assignee: InspireMD, Ltd.
• Original Assignee: InspireMD, Ltd.
• Inventors: Paz, Ofir, Bar, Eli, Holzer, Asher
• Application Number:
  US12/445,972
• Publication Number:
  US 20100204772A1
• Time in Patent Office: Days
• US Class Current: 623/1.110
• CPC Class Codes: A61F 2/01 Filters implantable into blood vessels
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/008 paraboloidal

Abstract

Disclosed is a filter assembly, comprising: a radially expandable vascular flow-increasing device, and a filter including an expandable proximal opening having an operative connection with the radially expandable vascular flow-increasing device, the proximal opening configured to expand in conjunction with expansion of the device, such that when the opening is in an expanded configuration, the filter is configured to filter debris from a fluid stream in which the filter is disposed.

Claims

1. A filter assembly, comprising:

a) a radially expandable vascular flow-increasing device; and

b) a filter including an expandable proximal opening having an operative connection with said radially expandable vascular flow-increasing device, said proximal opening configured to expand in conjunction with expansion of said device, such that when said opening is in an expanded configuration, said filter is configured to filter debris from a fluid stream in which said filter is disposed.

2. The assembly according to claim 1, wherein said radially expandable vascular flow-increasing device comprises:

a) at least one balloon configured to volumetrically expand and, during at least a portion of said expansion, operatively connect with said filter, and to contract following said expansion;

and

b) said operative connection comprises an operative connection between said filter and said at least one balloon during at least a portion of said volumetric expansion of said at least one balloon.

3. The assembly according to claim 2, wherein said at least one balloon comprises at least one proximal portion and at least one distal portion.

4. The assembly according to claim 3, wherein said filter operatively connects with said balloon at least one of:

said at least one proximal portion; and

said at least one distal portion.

5. The assembly according to claim 3, wherein a maximal expansion diameter of said at least one distal portion of said at least one balloon is greater than a maximal expansion diameter of said at least one proximal portion of said at least one balloon.

6. The assembly according to claim 3, wherein a maximal expansion diameter of said at least one proximal portion of said at least one balloon is greater than a maximal expansion diameter of said at least one distal portion of said at least one balloon.

7. The assembly according to claim 2, wherein said at least one balloon comprises at least one angioplasty balloon.

8. The assembly according to claim 2, wherein at least a portion of said filter is configured to remain removably connected to a luminal aspect during said contraction of said at least one balloon.

9. The assembly according to claim 8, including at least one cord operatively associated with said filter and configured to disconnect at least a portion of said filter from said luminal aspect when tension is applied to said at least one cord.

10. The assembly according to claim 2, wherein at least a portion of said filter includes a pressure-sensitive adhesive having an affinity for a tissue associated with an in vivo luminal aspect.

11. The assembly according to claim 10, wherein said adhesive is an adhesive from the group of adhesives comprising fibrin, biological glue, collagen, hydrogel, hydrocolloid, collagen alginate, and methylcellulose.

12. The assembly according to claim 10, wherein at least a portion of said filter is configured to remain removably connected to said luminal aspect during said contraction of said at least one balloon.

13. The assembly according to claim 12, including at least one cord operatively associated with said filter and configured to disconnect said at least a portion of said filter from said luminal aspect when tension is applied to said at least one cord.

14. The assembly according to claim 8, including a compression sleeve comprising a substantially curved wall having a proximal end, a distal end and a lumen extending from said proximal end to said distal end, said lumen having a cross sectional diameter that is substantially smaller than the maximal cross sectional diameter of said luminal aspect.

15. The assembly according to claim 14, including at least one cord operatively associated with said filter, at least a portion of said at least one cord movingly juxtaposed within said compression sleeve lumen.

16. The assembly according to claim 15 wherein when said at least one cord operatively associated with said filter is held relatively stationary during a first distal moving of said compression sleeve, said filter is caused to disconnect from said luminal aspect.

17. The assembly according to claim 15, wherein in response to at least one second distal moving of said sleeve while said at least one cord is held relatively stationary, said filter is caused to radially contract such that a maximal cross sectional diameter of said filter is smaller that a cross sectional diameter of said sleeve lumen.

18. The assembly according to claim 17, wherein in response to at least one third distal moving of said sleeve while said at least one cord is held stationary, at least a portion of said filter is caused to enter said sleeve lumen.

19. The assembly according to claim 9, wherein:

i) said at least one balloon comprises an outer wall having a distal end and a proximal end and an inner wall defining a lumen, said lumen extending from said distal end to said proximal end; and

ii) at least a portion of said at least one cord is configured to slidingly pass through said lumen.

20. The assembly according to claim 19, wherein said at least one cord is configured to pull at least a portion of said filter into contact with said distal end of said at least one balloon.

21. The assembly according to claim 2, wherein said filter includes a distal portion, a proximal portion, an opening to said filter associated with said proximal portion and at least one strut operatively associated with said proximal portion.

22. The assembly according to claim 21, including at least one cord operatively associated with said at least one strut, such that at least a portion of said opening is configured to contract radially inwardly in response to tension applied to said at least one cord.

23. The assembly according to claim 22, wherein said at least one strut comprises at least two struts, at least one first strut and at least one second strut, said at least two struts being operatively associated with said at least one cord.

24. The assembly according to claim 23, wherein said at least two struts are configured to resiliently flex outward with respect to a longitudinal axis passing through a center of said filter during at least a portion of said volumetric expansion of said at least one balloon.

25. The assembly according to claim 24, wherein during at least a portion of said outward flexion of said at least two struts:

said at least one first strut forms at least one first radius; and

said at least one second strut forms at least one second radius,

with respect to said longitudinal axis.

26. The assembly according to claim 2, wherein said filter includes:

a) a distal portion;

b) a proximal portion;

c) an opening to said filter associated with said proximal portion; and

d) at least one cord guide channel circumferentially encircling at least a portion said proximal portion.

27. The assembly according to claim 26, including at least one cord, at least a portion of said at least one cord passes through said guide channel, such that at least a portion of said opening is configured to contract radially inwardly in response to tension applied to said at least one cord.

28. The assembly according to claim 2, wherein said radially expandable vascular flow-increasing device comprises:

i) at least one balloon configured to volumetrically expand and, during at least a portion of said expansion, operatively connect with a filter, and, following said connection, to contract following said expansion;

ii) said filter comprises a material having tissue connective properties for a portion of luminal tissue associated with an in vivo fluid stream; and

iii) said operative connection comprises an operative connection between said filter and said at least one balloon during at least a portion of said volumetric expansion of said at least one balloon.

29. The assembly according to claim 1, wherein said radially expandable vascular flow-increasing device comprises:

a) a radially expandable stent configured to open a stenotic lumen, said radially expandable stent having a proximal end, a distal end and a lumen connecting said proximal and said distal ends;

b) an expandable balloon mounted on a distal portion of an elongate catheter, said expandable balloon configured to expand within said lumen of said expandable stent and cause said expandable stent to expand; and

c) said operative connection comprises an operative connection between said filter and said expandable stent.

30. The assembly according to claim 29, wherein said filter comprises a billowing filter.

31. The assembly according to claim 29, wherein said expandable opening of said filter is removably connected to said stent.

32. The assembly according to claim 31, including at least one cord operatively associated with said filter and configured to disconnect at least a portion of said filter from said expandable stent when tension is applied to said at least one cord.

33. The assembly according to claim 29, wherein said expandable opening of said filter is operatively connected with said stent such that expansion of said stent causes expansion of said expandable opening of said filter.

34. The assembly according to claim 1, wherein said radially expandable vascular flow-increasing device comprises:

a) a radially expandable stent configured to open a stenotic lumen, said radially expandable stent having a proximal end, a distal end and a lumen connecting said proximal and said distal ends; and

b) said operative connection comprises an operative connection between said filter and said expandable stent.

35. The assembly according to claim 34, wherein said expanding stent is self-expanding.

36. The assembly according to claim 35, including a stent holding spindle operatively associated with said stent when said stent is in a contacted configuration, said spindle being mounted on a distal portion of an elongate catheter.

37. The assembly according to claim 36, wherein said stent holding spindle includes a channel.

38. The assembly according to claim 37, including at least one cord operatively associated with said filter, at least a portion of said at least one cord being configured to slidingly pass through said channel through said spindle.

39. The assembly according to claim 38, wherein said at least one cord is configured to pull at least a portion of said filter opening into contact with at least a portion of said spindle.

40. The assembly according to claim 1, wherein said radially expandable vascular flow-increasing device comprises:

a) a radially expandable stent configured to open a stenotic lumen, said radially expandable stent having a proximal end, a distal end and a lumen connecting said proximal and said distal ends;

b) a jacket substantially surrounding an exterior surface of said expandable stent, said jacket configured in to expand in conjunction with expansion of said expanding stent; and

c) said operative connection comprises an operative connection between said filter and said jacket.

41. The assembly according to claim 40, wherein said stent comprises a self-expanding stent and said assembly includes a compression sleeve comprising a substantially curved wall having a proximal end, a distal end and a lumen extending from said proximal end to said distal end, said compression sleeve configured to slidingly encircle said stent when said stent is in a contracted configuration.

42. The assembly according to claim 41, including at least one cord, a portion of said at least one cord being movingly juxtaposed within said compression sleeve lumen.

43. The assembly according to claim 41, wherein said filter includes at least one cord guide channel circumferentially encircling at least a portion said proximal opening of said filter.

44. The assembly according to claim 43, including at least one cord, at least a portion of said at least one cord passes through said guide channel, such that at least a portion of said opening is configured to contract radially inwardly in response to tension applied to said at least one cord.

45. The assembly according to claim 40, including a belt that provides said operative connection between said jacket and said filter.

46. The assembly according to claim 45, wherein said belt is looped in at least one loop that removable connects said expandable opening of said filter with said jacket.

47. The assembly according to claim 46, wherein a tension applied to said belt causes said loop to disconnect from said expandable opening of said filter with said jacket, thereby removing said operative connection between said opening to said filter and said jacket.

48. The assembly according to claim 45, wherein said belt includes at least one connector that removably connects said filter to said jacket, said at least one connector from the group comprising a hook and a zipper.

49. A method for collecting debris while applying an expandable vascular flow-increasing device to a primary stenotic vessel and preventing passage of the debris into a branch vessel branching from said primary vessel, the method comprising:

a) detecting a stenotic lesion in said primary stenotic vessel;

b) locating a filter in said primary stenotic vessel such that an opening of said filter is distal to a center of said stenotic lesion;

c) locating at least a proximal portion of an expandable vascular flow-increasing device proximal to said opening in said filter;

d) expanding said expandable vascular flow-increasing device;

e) contacting said opening of said filter with at least a distal portion of said expandable vascular flow-increasing device during said expanding;

f) causing said filter to open during said contacting;

g) generating debris from said stenotic lesion by said expanding of said expandable vascular flow-increasing device;

h) capturing said debris in said filter;

i) contracting said filter; and

j) removing said filter from said primary stenotic vessel.

50. A method for collecting debris while applying an expandable vascular flow-increasing device to a stenotic vessel, the method comprising:

a) juxtaposing an opening of an in vivo debris filter with a radially expandable vascular flow-increasing device;

b) expanding said expandable vascular flow-increasing device in a blood vessel,

c) opening said filter during said expansion of said expandable vascular flow-increasing device,

d) collecting debris within said filter;

e) disengaging said filter from said expandable vascular flow-increasing device;

f) contracting said filter; and

g) removing said filter from said vessel.