METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS

• US 20100204783A1
• Filed: 11/27/2009
• Published: 08/12/2010
• Est. Priority Date: 12/06/2005
• Status: Abandoned Application

• Current Assignee: Shire Regenerative Medicine Incorporated (Shire plc)
• Original Assignee: Shire Regenerative Medicine Incorporated (Shire plc)
• Inventors: Dalal, Anupam, Bollinger, Stephen August, NUGENT, HELEN MARIE, Edelman, Elazer, Epperly, Scott
• Application Number:
  US12/626,823
• Publication Number:
  US 20100204783A1
• Time in Patent Office: Days
• US Class Current: 623/1.410
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61M 1/3655 Arterio-venous shunts or fistulae

Abstract

Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality.

Claims

1. An arteriovenous graft or fistula, further comprising:

(a) cells; and

,

(b) a biocompatible matrix.

2. The arteriovenous graft or fistula of claim 1, wherein the cells are endothelial cells or cells having an endothelial-like phenotype.

3. The arteriovenous graft of fistula of claim 2, wherein the cells are human.

4. The arteriovenous graft or fistula of claim 1, wherein the biocompatible matrix is a flexible planar material.

5. The arteriovenous graft or fistula of claim 1, wherein the biocompatible matrix is flowable.

6. The arteriovenous graft or fistula of claim 4, wherein the biocompatible matrix defines a slot.

7. The arteriovenous graft or fistula of claim 4, wherein the matrix is configured as in FIG. 1 or 2A.

8. The arteriovenous graft or fistula of claim 5, wherein the flowable composition is a shape-retaining composition.

9. The arteriovenous graft or fistula of claim 1, wherein the cells are selected from the group consisting of:

a confluent population of cells;

a near confluent population of cells;

a post confluent population of cells; and

cells which have a phenotype of any one of the foregoing population of cells.

10. The arteriovenous graft or fistula of claim 4, wherein the biocompatible matrix is an absorbable gelatin sponges.

11. The arteriovenous graft or fistula of claim 1, wherein the biocompatible matrix further comprise an attachment factor.

12. The arteriovenous graft or fistula of claim 4, wherein the length of the flexible planar biocompatible matrix is of a size in the range of about 1 to about 10 cm.

13. The arteriovenous graft or fistula of claim 4, wherein the width of the flexible planar biocompatible matrix is in the range of about 0.1 to about 5 cm.

14. The arteriovenous graft or fistula of claim 4, wherein the height of the flexible planar biocompatible matrix is in the range of about 0.1 to about 5 cm.

15. A method for treating a vascular access structure in a patient, the method comprising the step of locating at, adjacent or in the vicinity of the vascular access structure in said patient an implantable material comprising cells and a biocompatible matrix, wherein the implantable material is effective to promote functionality of said structure.

16. The method of claim 15, wherein the vascular access structure is an fistula or graft.

17. The method of claim 15, wherein the cells are endothelial cells or cells having an endothelial-like phenotype.

18. The method of claim 15, wherein the biocompatible matrix is a flexible, planar material.

19. The method of claim 15, wherein the biocompatible matrix is flowable.

20. The method of claim 15, wherein the cells are selected from the group consisting of:

a confluent population of cells;

a near confluent population of cells;

a post confluent population of cells; and

cells which have a phenotype of any one of the foregoing population of cells.