RESONANT SENSORS AND METHODS OF USE THEREOF FOR THE DETERMINATION OF ANALYTES
First Claim
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1. A resonant sensor for determining the presence, amount or binding kinetics of an analyte in a test medium, said sensor being operable under the influence of an activating force field and comprising:
- an active, deformable planar member;
a passive, deformable planar member attached to said active, deformable planar member, forming a pliable, layered sensing element having a resonant flexural bending or extensional mode for analyte determination and at least one axis of symmetry; and
a capture agent for said analyte associated with at least one exterior surface site of said sensing element,said sensing element with associated capture agent being caused to vibrate at a determinable resonance frequency by said activating force field operating on said active, deformable planar member, said activating force field inducing in said sensing element a uniform bending moment or extensional force component that is substantially parallel or perpendicular to said at least one axis of symmetry.
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Abstract
Resonant sensors, preferably having floating bilayer symmetry, and their methods of use is determining the presence, amount or binding kinetics of an analyte of interest in a test sample are disclosed. The test sample may be a liquid or gas.
101 Citations
45 Claims
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1. A resonant sensor for determining the presence, amount or binding kinetics of an analyte in a test medium, said sensor being operable under the influence of an activating force field and comprising:
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an active, deformable planar member; a passive, deformable planar member attached to said active, deformable planar member, forming a pliable, layered sensing element having a resonant flexural bending or extensional mode for analyte determination and at least one axis of symmetry; and a capture agent for said analyte associated with at least one exterior surface site of said sensing element, said sensing element with associated capture agent being caused to vibrate at a determinable resonance frequency by said activating force field operating on said active, deformable planar member, said activating force field inducing in said sensing element a uniform bending moment or extensional force component that is substantially parallel or perpendicular to said at least one axis of symmetry. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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Specification