Compositions of stem cells and stem cell factors and methods for their use and manufacture
First Claim
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1. A kit for regenerative stem cell therapy comprising:
- a. a therapeutic amount of neural stem cells in a pharmaceutically acceptable carrier; and
b. a therapeutic amount of mesenchymal stem cells in a pharmaceutically acceptable carrier;
c. wherein the neural stem cells and the mesenchymal stem cells have been exposed to at least one environmental factor.
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Abstract
Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension. The environmental factors and culture conditions of the invention produce stem cells having an enhanced therapeutic ability and enhanced proliferation in culture. Stem cells of the invention retain their plasticity through a higher number of cell passages relative to know methods of stem cell culture.
37 Citations
20 Claims
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1. A kit for regenerative stem cell therapy comprising:
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a. a therapeutic amount of neural stem cells in a pharmaceutically acceptable carrier; and b. a therapeutic amount of mesenchymal stem cells in a pharmaceutically acceptable carrier; c. wherein the neural stem cells and the mesenchymal stem cells have been exposed to at least one environmental factor. - View Dependent Claims (2, 3, 4, 5)
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6. A method for treating a medical disorder in a patient comprising:
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a. administering to the patient a therapeutic amount of neural stem cells; and b. administering to the patient a therapeutically effective amount mesenchymal stem cells; c. wherein the neural stem cells and the mesenchymal stem cells have been contacted with at least one environmental factor. - View Dependent Claims (7, 8, 9, 10)
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11. A method for treating a medical disorder in a patient comprising:
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a. administering to the patient a therapeutically effective amount mesenchymal stem cells; b. wherein the mesenchymal stem cells have been contacted with at least one environmental factor. - View Dependent Claims (12, 13, 14, 15, 16)
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17. A kit for the treatment of a medical disorder comprising:
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a. an effective amount of stem cell factors derived from neural stem cells; b. an effective amount of stem cell factors derived from mesenchymal stem cells; c. wherein the neural stem cells and mesenchymal stem cells are exposed to at least one environmental factor. - View Dependent Claims (18, 19, 20)
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Specification