Methods For Treating Withdrawal From Addictive Compounds
First Claim
Patent Images
1. A method, comprising:
- a) providing,i) a subject experiencing at least one withdrawal symptom induced by at least one addictive compound;
ii) a Kratom extract capable of reducing or preventing said at least one withdrawal symptom; and
b) administering said Kratom extract to said subject under conditions such that said at least one withdrawal symptom is prevented or reduced.
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Abstract
Kratom (Mitragynia speciosa korth) is recognized increasingly as a remedy for opioid withdrawal by individuals who self-treat chronic pain and/or generalized substance abuse. For example, opioid withdrawal from an abrupt cessation of opiate abuse may be self-managed by using Kratom. Further, high-throughput molecular screening identified that a major component of Kratom (i.e., for example, mitragyinine) displayed high binding affinity at mu, delta and kappa opiate receptors. The present invention contemplates that Kratom extract may also be useful for the treatment of other addictive drugs besides opiate derivatives.
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Citations
26 Claims
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1. A method, comprising:
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a) providing, i) a subject experiencing at least one withdrawal symptom induced by at least one addictive compound; ii) a Kratom extract capable of reducing or preventing said at least one withdrawal symptom; and b) administering said Kratom extract to said subject under conditions such that said at least one withdrawal symptom is prevented or reduced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method, comprising:
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a) providing, i) a subject repeatedly exposed to at least one addictive compound, wherein said subject is at risk of experiencing at least one withdrawal symptom; ii) a composition comprising mitragynine, wherein said composition is capable of reducing or preventing said at least one withdrawal symptom; and b) administering said composition to said subject under conditions such that said at least one withdrawal symptom is prevented or reduced. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method, comprising:
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a) providing; i) a subject repeatedly exposed to at least one addictive opioid compound, wherein said subject is at risk of experiencing at least one opioid withdrawal symptom; ii) a composition comprising mitragynine, wherein said composition is capable of reducing or preventing said at least one withdrawal symptom; and administering said composition to said subject under conditions such that said at least one withdrawal symptom is prevented and/or reduced. - View Dependent Claims (22, 23, 24, 25, 26)
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Specification