PLASMODIUM AXENIC LIVER STAGES AS A NONINFECTIOUS WHOLE ORGANISM MALARIA VACCINE
First Claim
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1. A method for the generation of a Plasmodium falciparum axenic liver stage exoerythrocytic form (EEF), which method comprises culturing a Plasmodium falciparum sporozoite in the absence of a hepatocyte, wherein the Plasmodium sporozoite is cultured at a temperature between about 35°
- C. and about 39°
C. in culture medium comprising serum and wherein the method does not require host cells.
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Abstract
The present invention relates to the treatment and prevention of malaria infection. In particular, the present invention provides novel noninfectious, whole organism vaccines for malaria, which vaccines comprise a Plasmodium axenic liver stage. The invention also provides methods to treat and prevent malaria by administering such Plasmodium axenic liver stage vaccines, as well as methods to generate Plasmodium axenic liver stages.
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Citations
13 Claims
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1. A method for the generation of a Plasmodium falciparum axenic liver stage exoerythrocytic form (EEF), which method comprises culturing a Plasmodium falciparum sporozoite in the absence of a hepatocyte, wherein the Plasmodium sporozoite is cultured at a temperature between about 35°
- C. and about 39°
C. in culture medium comprising serum and wherein the method does not require host cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- C. and about 39°
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13-23. -23. (canceled)
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