METHOD OF SYNTHESIS AND TESTING OF COMINATORIAL LIBRARIES USING MICROCAPSULES
First Claim
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1. A method of forming a small molecule compound comprising:
- providing at least a first aqueous fluid comprising at least a first small molecule compound having a molecular weight of less than 500 Daltons;
providing at least a second aqueous fluid comprising at least a second small molecule compound having a molecular weight of less than 500 Daltons;
encapsulating said at least first small molecule compound into at least a first aqueous microcapsule within an immiscible fluorocarbon oil;
encapsulating said at least second small molecule compound into at least a second aqueous microcapsule within an immiscible fluorocarbon oil; and
fusing said at least first and said at least second aqueous microcapsules, thereby causing a chemical reaction between said at least first and at least second small molecule compounds to form at least a third small molecule compound.
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Abstract
Methods for use in the synthesis and identification of molecules which bind to a target component of a biological system or modulate the activity of a target are described.
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12 Claims
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1. A method of forming a small molecule compound comprising:
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providing at least a first aqueous fluid comprising at least a first small molecule compound having a molecular weight of less than 500 Daltons; providing at least a second aqueous fluid comprising at least a second small molecule compound having a molecular weight of less than 500 Daltons; encapsulating said at least first small molecule compound into at least a first aqueous microcapsule within an immiscible fluorocarbon oil; encapsulating said at least second small molecule compound into at least a second aqueous microcapsule within an immiscible fluorocarbon oil; and fusing said at least first and said at least second aqueous microcapsules, thereby causing a chemical reaction between said at least first and at least second small molecule compounds to form at least a third small molecule compound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification