RNAi Inhibition of Alpha-ENaC Expression
First Claim
Patent Images
1. A composition comprising an iRNA agent comprising a sense strand and an antisense strand, wherein:
- a. the sense strand comprises at least 15 contiguous nucleotides from the sense strand of ND8496 (SEQ ID NO;
1511), and the antisense strand comprises at least 15 contiguous nucleotides from the antisense strand of ND8496 (SEQ ID NO;
1512);
orb. the sense strand comprises at least 15 contiguous nucleotides differing by 0, 1, 2 or 3 nucleotides from the sense strand of ND8712 (SEQ ID NO;
1637), and the antisense strand comprises at least 15 contiguous nucleotides differing by 0, 1, 2 or 3 nucleotides from the antisense strand of ND8712 (SEQ ID NO;
1638).
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Abstract
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
23 Citations
19 Claims
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1. A composition comprising an iRNA agent comprising a sense strand and an antisense strand, wherein:
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a. the sense strand comprises at least 15 contiguous nucleotides from the sense strand of ND8496 (SEQ ID NO;
1511), and the antisense strand comprises at least 15 contiguous nucleotides from the antisense strand of ND8496 (SEQ ID NO;
1512);
orb. the sense strand comprises at least 15 contiguous nucleotides differing by 0, 1, 2 or 3 nucleotides from the sense strand of ND8712 (SEQ ID NO;
1637), and the antisense strand comprises at least 15 contiguous nucleotides differing by 0, 1, 2 or 3 nucleotides from the antisense strand of ND8712 (SEQ ID NO;
1638). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 17, 18, 19)
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15. A composition comprising an iRNA agent to alpha-ENaC, wherein the iRNA agent comprises
a sense strand and an antisense strand, wherein the sense strand comprises at least 15 contiguous nucleotides differing by 0, 1, 2, or 3 nucleotides from the sense strand of an iRNA agent selected from the group consisting of ND8496 (SEQ ID NO: - 1511) and ND8712 (SEQ ID NO;
1637), andwherein the antisense strand comprises at least 15 contiguous nucleotides differing by 0, 1, 2, or 3 nucleotides from the antisense strand of an iRNA agent selected from the group consisting of ND8496 (SEQ ID NO;
1512) and ND8712 (SEQ ID NO;
1638), the composition further comprising an epithelial receptor ligand. - View Dependent Claims (16)
- 1511) and ND8712 (SEQ ID NO;
Specification