Swellable Crosslinked Hyaluronan Powder And Method For Producing The Same
First Claim
1. A swellable crosslinked hyaluronan powder having a swelling ratio in water of 500% or more.
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Abstract
The present invention is provides a crosslinked hyaluronan powder excellent in swellability in water and a method for simply producing the same. A method for producing the swellable crosslinked hyaluronan powder is characterized by comprising mixing a crosslinking agent with a hyaluronan powder in a state dispersed in a liquid medium containing a monovalent alcohol having 1 to 4 carbon atoms and a solubility of the hyaluronan powder of less than 0.1 g/L to cause a crosslinking reaction. Also, the swellable crosslinked hyaluronan powder produced by the method has a swelling ratio in water of 500% or more.
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Citations
20 Claims
- 1. A swellable crosslinked hyaluronan powder having a swelling ratio in water of 500% or more.
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3. A method for producing a swellable crosslinked hyaluronan powder, comprising
(a) dispersing a hyaluronan powder in a liquid medium, wherein the liquid medium includes a monovalent alcohol having 1 to 4 carbon atoms, wherein the hyaluronan powder is soluble therein to an extent of less than 0.1 g/L, and (b) mixing a crosslinking agent with a the dispersed hyaluronan powder to cause a crosslinking reaction.
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9. A method for producing a swellable crosslinked hyaluronan powder, comprising:
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(1) mixing a crosslinking agent with a hyaluronan powder in a state dispersed in a solvent containing a monovalent alcohol having 1 to 4 carbon atoms and an alkaline buffer solution and having a solubility of the hyaluronan powder of less than 0.1 g/L to cause a crosslinking reaction, and (2) mixing a crosslinking agent with the product in the step (1) in a state dispersed in a solvent containing a monovalent alcohol having 1 to 4 carbon atoms and an acidic buffer solution and having a solubility of the hyaluronan powder of less than 0.1 g/L to cause a crosslinking reaction. - View Dependent Claims (10, 11, 20)
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Specification