Methods of Treatment of Opioid Tolerance, Physical Dependence, Pain and Addiction With Inhibitors of Certain Growth Factor Receptors
First Claim
1. A method of treating opioid tolerance comprising the step of administering to a subject in need thereof a therapeutically effective amount of a PDGFR modulator wherein said modulator is administered to the subject in an aqueous pharmaceutical formulation comprising cyclodextrin, cyclodextran, or other cycloamyloses.
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Accused Products
Abstract
Methods of preventing the development and reversing or partially reversing opioid tolerance in a subject are provided herein. Such methods include the step of administering to a subject in need thereof a therapeutically effective amount of a PDGFR modulator or EGFR modulator alone or together with an opiate analgesic. The methods can also be used for the treatment of refractory neuropathic pain, physical dependence or addiction.
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Citations
17 Claims
- 1. A method of treating opioid tolerance comprising the step of administering to a subject in need thereof a therapeutically effective amount of a PDGFR modulator wherein said modulator is administered to the subject in an aqueous pharmaceutical formulation comprising cyclodextrin, cyclodextran, or other cycloamyloses.
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7. A method of treating pain comprising the step of administering to a subject in need thereof a therapeutically effective amount of Imatinib wherein Imatinib is provided in an aqueous pharmaceutical formulation.
- 8. A method of treating opioid tolerance comprising the step of administering to a subject in need thereof a therapeutically effective amount of a EGFR modulator wherein said modulator is administered to the subject in an aqueous pharmaceutical formulation comprising cyclodextrin, cyclodextran, or other cycloamyloses.
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9. The method of claim 9 wherein the subject is administered the EGFR modulator in combination with an opioid.
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14. A pharmaceutical aqueous formulation comprising:
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cyclodextrin; and an EGFR small molecule inhibitor. - View Dependent Claims (16)
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15. A pharmaceutical aqueous formulation comprising:
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cyclodextrin; and a PDGFR small molecule inhibitor. - View Dependent Claims (17)
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Specification