Immunocytokine Sequences and Uses Thereof
3 Assignments
0 Petitions
Accused Products
Abstract
The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coupled to a therapeutic agent and used in the treatment of cancer.
99 Citations
12 Claims
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1-5. -5. (canceled)
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6. A nucleic acid encoding an amino acid sequence comprising SEQ ID NO:
- 1, amino acids 1-25 of SEQ ID NO;
2, or amino acids 67-98 of SEQ ID NO;
2. - View Dependent Claims (7, 8, 9, 10, 11)
- 1, amino acids 1-25 of SEQ ID NO;
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12-26. -26. (canceled)
Specification