DELIVERY OF THERAPEUTICALLY/DERMATOLOGICALLY ACTIVE SPECIES INTO THE SKIN VIA ELECTROPORATION
First Claim
1. A regime or regimen for treating a skin disease, disorder or condition afflicting a patient in need thereof,which method comprisesa) forming at least one micropore to a predetermined depth through a surface of the afflicted skin of said patient;
- b) positioning at least a first electrode on the surface of the skin electrically coupled to the at least one micropore and a second electrode on the surface of the skin spaced apart from the first electrode;
c) applying an electrical voltage from the first and second electrodes to produce a desired electroporation in the skin,and further comprising the step d) of delivering a biologically active species to the skin at the at least two micropores formed therein, wherein the said biologically active species is therapeutically/dermatologically active against said skin disease, disorder or condition.
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Accused Products
Abstract
A regime or regimen for treating a skin disease, disorder or condition afflicting a patient in need thereof includes forming at least one micropore to a predetermined depth through a surface of the afflicted skin of such patient; positioning at least a first electrode on the surface of the afflicted skin electrically coupled to the at least one micropore and a second electrode on the surface of the afflicted skin spaced apart from the first electrode; applying an electrical voltage from the first and second electrodes to produce a desired electroporation in the skin, and further including the step of delivering a biologically active species to the afflicted skin at the at least two micropores formed therein, wherein the biologically active species is therapeutically/dermatologically active against the skin disease, disorder or condition.
51 Citations
21 Claims
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1. A regime or regimen for treating a skin disease, disorder or condition afflicting a patient in need thereof,
which method comprises a) forming at least one micropore to a predetermined depth through a surface of the afflicted skin of said patient; -
b) positioning at least a first electrode on the surface of the skin electrically coupled to the at least one micropore and a second electrode on the surface of the skin spaced apart from the first electrode; c) applying an electrical voltage from the first and second electrodes to produce a desired electroporation in the skin, and further comprising the step d) of delivering a biologically active species to the skin at the at least two micropores formed therein, wherein the said biologically active species is therapeutically/dermatologically active against said skin disease, disorder or condition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A regime or regimen for treating a skin disease, disorder or condition afflicting a patient in need thereof, which method comprises:
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a) forming at least one micropore to a predetermined depth through a surface of the skin by placing an electrically heated probe at the surface of the afflicted skin and supplying electrical current to the electrically heated probe so as to ablate the surface of the afflicted skin to form the at least one micropore; b) positioning at least a first electrode electrically coupled to the at least one micropore and a second electrode spaced apart from the first electrode; c) applying an electrical voltage from the first and second electrodes to produce a desired electroporation in the skin, and further comprising the step d) of delivering a biologically active species to the skin at the at least two micropores formed therein, wherein said biologically active species is therapeutically/dermatologically active against said disease, disorder or condition. - View Dependent Claims (20)
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21. A regime or regimen for treating a skin disease, disorder or condition afflicting a patient in need thereof, which method comprises:
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a) forming at least one micropore to a predetermined depth through a surface of the afflicted skin by placing first and second electrically heated probes at the surface of the skin spaced apart from each other and supplying electrical current to each of the first and second electrically heated probes such as to ablate the surface of the afflicted skin in order to form two micropores spaced apart from each other; b) positioning at least a first electrode electrically coupled to the at least one micropore and a second electrode spaced apart from the first electrode; c) applying an electrical voltage from the first and second electrodes to produce a desired electroporation in the afflicted skin. and further comprising the step d) of delivering a biologically active species to the skin at the at least two micropores formed therein, wherein the biologically active species is therapeutically/dermatologically active against said disease, disorder or condition.
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Specification