STENTS HAVING BIODEGRADABLE LAYERS
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Accused Products
Abstract
Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
144 Citations
118 Claims
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1-98. -98. (canceled)
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99. A coated stent comprising
a. a stent framework; b. a plurality of layers deposited on said stent framework to form said coated stent;
wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents;
wherein at least part of the active agent is in crystalline form.- View Dependent Claims (100, 101, 102, 103, 104, 105, 106, 107, 108)
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109. A method of preparing a coated stent comprising:
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a. providing a stent framework; b. depositing a plurality of layers on said stent framework to form said coated stent;
wherein at least one of said layers comprises a bioabsorbable polymer;
wherein depositing each layer of said plurality of layers on said stent framework comprises the following steps;discharging at least one pharmaceutical agent and/or at least one active biological agent in dry powder form though a first orifice; discharging the at least one polymer in dry powder form through said first orifice or through a second orifice; depositing the polymer and pharmaceutical agent and/or active biological agent particles onto said framework, wherein an electrical potential is maintained between the framework and the polymer and pharmaceutical agent and/or active biological agent particles, thereby forming said layer; and sintering said layer under conditions that do not substantially modify the morphology of said pharmaceutical agent and/or the activity of said biological agent. - View Dependent Claims (112, 113, 114, 115, 116, 117, 118)
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110. A method of preparing a coronary stent comprising:
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a. providing a stent framework; b. depositing a plurality of layers on said stent framework to form said coronary stent;
wherein at least one of said layers comprises a bioabsorbable polymer;
at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent;
wherein depositing each layer of said plurality of layers on said stent framework comprises the following steps;i. discharging the at least one pharmaceutical agent and/or at least one active biological agent in dry powder form through a first orifice; ii. forming a supercritical or near supercritical fluid solution comprising at least one supercritical fluid solvent and at least one polymer and discharging said supercritical or near supercritical fluid solution through a second orifice under conditions sufficient to form solid particles of the polymer; iii. depositing the polymer and pharmaceutical agent and/or active biological agent particles onto said framework, wherein an electrical potential is maintained between the framework and the polymer and pharmaceutical agent and/or active biological agent particles, thereby forming said layer; and iv. sintering said layer under conditions that do not substantially modify the morphology of said pharmaceutical agent and/or the activity of said biological agent.
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111. A method of preparing a coronary stent comprising:
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a. providing a stent framework; b. depositing a plurality of layers on said stent framework to form said coronary stent;
wherein at least one of said layers comprises a bioabsorbable polymer;
at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent;
wherein depositing each layer of said plurality of layers on said stent framework comprises the following steps;i. forming a supercritical or near supercritical fluid solution comprising at least one supercritical fluid solvent and one or more pharmaceutical agents and/or at least one active biological agent discharging said supercritical or near supercritical fluid solution through a first orifice under conditions sufficient to form solid particles of said one or more pharmaceutical agents and/or at least one active biological agent; ii. forming a supercritical or near supercritical fluid solution comprising at least one supercritical fluid solvent and at least one polymer and discharging said supercritical or near supercritical fluid solution through said first orifice or through a second orifice under conditions sufficient to form solid particles of the polymer; iii. depositing the polymer and pharmaceutical agent and/or active biological agent particles onto said framework, wherein an electrical potential is maintained between the framework and the polymer and pharmaceutical agent and/or active biological agent particles, thereby forming said layer; and iv. sintering said layer under conditions that do not substantially modify the morphology of said pharmaceutical agent and/or the activity of said biological agent.
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Specification