CALCIUM-CONTAINING RESTORATION MATERIALS
First Claim
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1. A composition of matter for dental restoration and bone implants and restoration comprising, in combination:
- a non-toxic non-aqueous water-miscible liquid;
a powdered calcium compound selected from the group consisting of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, dicalcium phosphate dehydrate, octacalcium phosphate, α
-tricalcium phosphate, β
-tricalcium phosphate, amorphous calcium phosphate, calcium deficient hydroxyapatite, non-stoichiometric hydroxyapatite, tetracalcium phosphate, CaSO4, CaSO4.0.5H2O, CaSO4.2H2O, CaO, Ca(OH)2, CaCO3 and mixtures thereof; and
an organic acid for forming calcium complexes when reacted with the calcium compound in the presence of water.
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Abstract
A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders, liquid glycerol, organic acid and gelling agent. The paste is stable, resistant to washout and will harden upon exposure to water. Physical characteristics of the paste, including consistency, porosity, and hardening time, are controlled by the choice and ratio of constituents.
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Citations
37 Claims
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1. A composition of matter for dental restoration and bone implants and restoration comprising, in combination:
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a non-toxic non-aqueous water-miscible liquid; a powdered calcium compound selected from the group consisting of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, dicalcium phosphate dehydrate, octacalcium phosphate, α
-tricalcium phosphate, β
-tricalcium phosphate, amorphous calcium phosphate, calcium deficient hydroxyapatite, non-stoichiometric hydroxyapatite, tetracalcium phosphate, CaSO4, CaSO4.0.5H2O, CaSO4.2H2O, CaO, Ca(OH)2, CaCO3 and mixtures thereof; andan organic acid for forming calcium complexes when reacted with the calcium compound in the presence of water. - View Dependent Claims (2, 3, 4, 5, 6, 20, 21, 22)
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7. A paste for bone and tooth restoration comprising, in combination:
- an essentially water-free mixture of calcium compound powder, a non-toxic non-aqueous water-miscible liquid and carboxylic acid.
- View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 23, 24, 25)
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18. A method of preparing a paste for bone and tooth restoration, the method comprising:
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(a) formulating a composition comprising a non-toxic, non-aqueous, water-miscible liquid including; (i) powder selected from the group consisting of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, dicalcium phosphate dehydrate, octacalcium phosphate, α
-tricalcium phosphate, β
-tricalcium phosphate, amorphous calcium phosphate, calcium deficient hydroxyapatite, non-stoichiometric hydroxyapatite, tetracalcium phosphate, CaSO4, CaSO4.0.5H2O, CaSO4.2H2O, CaO, Ca(OH)2, CaCO3 and mixtures thereof; and(ii) an organic acid for forming calcium complexes with the calcium powder, the composition being formulated under substantially anhydrous conditions; and (b) storing said composition under substantially anhydrous conditions. - View Dependent Claims (19, 26, 27, 28, 29, 30, 31, 32)
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33. A method of preparing a paste for bone and tooth restoration, said method comprising the following steps:
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(a) formulating a composition in the form of a non-toxic, non-aqueous, water-miscible liquid by mixing in a substantially anhydrous condition; a powdered calcium compound in the form of selectively sized powder particles, said particle size in the range of about 1 μ
m to 50 μ
m, said particles comprising a calcium compound selected from the group consisting of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, dicalcium phosphate dehydrate, octacalcium phosphate, α
-tricalcium phosphate, β
-tricalcium phosphate, amorphous calcium phosphate, calcium deficient hydroxyapatite, non-stoichiometric hydroxyapatite, tetracalcium phosphate, CaSO4, CaSO4.0.5H2O, CaSO4.2H2O, CaO, Ca(OH)2, CaCO3 and mixtures thereof;(ii) a carboxylic acid for accelerating hardening of said composition when said composition is exposed to water at a delivery site, said acid comprising an acid selected from the group consisting of glycolic, citric, tartaric, malonic, malic, and maleic acids and combinations thereof; (iii) a non-toxic, non-aqueous water-miscible liquid; and (iv) a gelling agent; said powder to liquid mass ratio is at least about 1.5, said components blended to obtain a substantially homogeneous formable anhydrous paste mixture; and (b) storing said paste mixture under substantially anhydrous conditions. - View Dependent Claims (34, 35, 36, 37)
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Specification