MEDICAL DEVICES INCORPORATING FUNCTIONAL ADHESIVES

• US 20100212829A1
• Filed: 02/19/2010
• Published: 08/26/2010
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Sofradim Production
• Original Assignee: Sofradim Production
• Inventors: Ladet, Sebastien, Gravagna, Philippe
• Granted Patent: US 8,535,477 B2
• Time in Patent Office: Days
• US Class Current: 156/325
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61L 15/22 containing macromolecular materials
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: Y10T 156/10 Methods of surface bonding and/or assembly therefor

Abstract

A method for bonding a polymeric medical device to tissue is provided which includes providing a polymeric medical device having a plurality of reactive members of a specific binding pair attached on a surface of the medical device, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the medical device with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. A kit is provided including a polymeric medical device such as a patch or mesh having a plurality of reactive members of a specific binding pair attached to a surface of the device and an applicator containing a solution or suspension of complementary reactive members of the specific binding pair, the complementary reactive members having a functionality that will adhere them to biological tissue upon contact, said applicator adapted to deliver the solution or suspension to biological tissue.

Claims

1. A method for bonding a polymeric medical device to biological tissue comprising:

providing a polymeric medical device having a plurality of reactive members of a specific binding pair attached on a surface of the medical device;

providing tissue having a plurality of complementary reactive members of the specific binding pair; and

contacting the medical device with the tissue, wherein upon contact of the reactive members on the surface of the medical device with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the medical device to the tissue.

2. The method for bonding a polymeric medical device to tissue according to claim 1 wherein the members of the specific binding pair bind to one another via a reaction selected from the group consisting of Huisgen cycloaddition reaction, a Diels-Alder reaction and a thiol-ene reaction.

3. The method for bonding a polymeric medical device to tissue according to claim 2 wherein the members of the specific binding pair are alkynes and azides.

4. The method for bonding a polymeric medical device to tissue according to claim 3 wherein the reactive member is an alkyne and the complementary reactive member is an azide.

5. The method for bonding a polymeric medical device to tissue according to claim 3 wherein the reactive members is an azide and the complementary reactive member is an alkyne.

6. The method for bonding a polymeric medical device to tissue according to claim 2 wherein the reaction is catalyzed by copper to activate an alkyne and an azide for [3+2] cycloaddition.

7. The method for bonding a polymeric medical device to tissue according to claim 2 wherein the reaction involves a cyclooctyne reagent and an azide for [3+2] cycloaddition.

8. The method for bonding a polymeric medical device to tissue according to claim 2 wherein the members of the specific binding pair are thiols and alkenes.

9. The method for bonding a polymeric medical device to tissue according to claim 4 wherein the members of the specific binding pair are dienes and alkenes.

10. The method for bonding a polymeric medical device to tissue according to claim 2 wherein the tissue is provided with complementary reactive members of the specific binding pair by applying a mixture or an aerosol containing the complementary reactive members to the tissue, the complementary reactive members being conjugated to a linker adapted to link the complementary reactive members to the tissue.

11. The method for bonding a polymeric medical device to tissue according to claim 10 wherein the complementary reactive members are attached to the tissue via an RGD linker.

12. The method for bonding a polymeric medical device to tissue according to claim 10 wherein the complementary reactive members are attached to the tissue via a ligand-receptor linkage.

13. The method for bonding a polymeric medical device to tissue according to claim 12 wherein the complementary reactive members are conjugated to a linker selected from the group consisting of antibody, Fab, F(ab′

)₂, Fv, single chain antibody (SCA) and single complementary-determining region (CDR).

14. The method for bonding a polymeric medical device to tissue according to claim 10 wherein the linker is degraded by hydrolysis or enzymatic action.

15. The method for bonding a polymeric medical device to tissue according to claim 10 wherein the ligand binds to a receptor selected from the group consisting of peptides, oligosaccharides, oligonucleotides and lipids.

16. The method for bonding a polymeric medical device to tissue according to claim 2 wherein the medical device is provided with the reactive members of the specific binding pair by surface modification techniques selected from the group consisting of plasma treatment, silane coupling treatment and acid sensitization.

17. The method for bonding a polymeric medical device to tissue according to claim 1 wherein the medical device is a mesh or a patch.

18. The method for bonding a polymeric medical device to tissue according to claim 17 wherein the patch is made of foam, woven material and non-woven material.

19. The method for bonding a polymeric medical device to tissue according to claim 1 wherein the medical device is made of a polymer selected from the group consisting of polycarbonates, polyolefins, polymethacrylates, polystyrenes, polyamides, polyurethanes, polyethylene terephthalate, poly (lactic acid), poly (glycolic acid), poly (hydroxbutyrate), dioxanones (e.g., 1,4-dioxanone), δ

-valerolactone, 1,dioxepanones (e.g., 1,4-dioxepan-2-one and 1,5-dioxepan-2-one), poly (phosphazine), polyesters, polyethylene glycol, polyethylene oxides, polyacrylamides, cellulose esters, fluoropolymers, vinyl polymers, silk, collagen, alginate, chitin, chitosan, hyaluronic acid, chondroitin sufate, polyhydroxyethylmethylacrylate, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid, polyacetate, polycaprolactone, polypropylene, glycerols, poly(amino acids), copoly (ether-esters), polyalkylene oxalates, polyamides, poly (iminocarbonates), polyalkylene oxalates, polyoxaesters, polyorthoesters, polyphosphazenes, polypeptides and copolymers, block copolymers, homoploymers, blends and combinations thereof.

20. A kit comprising a polymeric medical device having a plurality of reactive members of a specific binding pair attached to a surface of the device and an container containing a mixture which can be a solution or suspension of complementary reactive members of the specific binding pair, the complementary reactive members having a functionality adapted to adhere them to biological tissue upon contact, and an applicator adapted to deliver the solution or suspension to biological tissue.

21. A kit according to claim 20 further comprising a container for containing a solution of a metal.

22. A kit according to claim 20 further comprising a generator for generating microwaves or ultraviolet radiation.